Abnormal lymphocyte response to exogenous interleukin-2 in homosexuals with acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC)

J. L. Murray, E. M. Hersh, J. M. Reuben, C. G. Munn, P. W. Mansell

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Interleukin-2 (IL-2) production as well as the response of lymphocytes to exogenous IL-2 was measured in asymptomatic homosexuals, patients with acquired immune deficiency syndrome (AIDS), and homosexuals with prodromal symptoms. IL-2 production following lectin stimulation was not significantly different in homosexuals compared to age matched heterosexual controls. In contrast, the response of lymphocytes to exogenous IL-2 was significantly decreased in AIDS and homosexuals with prodromal symptoms compared to asymptomatic homosexuals and heterosexual controls. These data, combined with the data of others, suggest that an underlying immune defect in AIDS is abnormal IL-2 receptor expression and resultant poor IL-2 response.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalClinical and Experimental Immunology
Volume60
Issue number1
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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