Abstract
Following determination of ABO blood type at the sixth biennial examination, the Framingham Heart Study cohort was followed for the occurrence of cardiovascular events for a period of 10 years. A significant association was found between blood type and intermittent claudication, with blood group O showing the lowest rates. Slight but non-significant excesses for certain other CHD events were also found in non-O individuals. Serum cholesterol showed marginally significant but consistent elevations in non-O subjects but the increased risk in non-O individuals was found to occur independently of the known intermittent claudication risk factors. Since the observed relationship between blood type and intermittent claudication occurs independently of the usual atherosclerotic risk factors, blood type, possibly through an effect on clotting, should be considered in the pathogenesis of intermittent claudication.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 311-318 |
| Number of pages | 8 |
| Journal | Atherosclerosis |
| Volume | 25 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - 1976 |
| Externally published | Yes |
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Keywords
- ABO blood group
- Atherosclerosis
- Blood clotting
- Cardiovascular disease
- Epidemiology
- Human genetics
- Intermittent claudication
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
ABO blood group and cardiovacular disease the Framingham study. / Garrison, R. J.; Havlik, R. J.; Harris, Robin B; Feinleib, M.; Kannel, W. B.; Padgett, S. J.
In: Atherosclerosis, Vol. 25, No. 2-3, 1976, p. 311-318.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - ABO blood group and cardiovacular disease the Framingham study
AU - Garrison, R. J.
AU - Havlik, R. J.
AU - Harris, Robin B
AU - Feinleib, M.
AU - Kannel, W. B.
AU - Padgett, S. J.
PY - 1976
Y1 - 1976
N2 - Following determination of ABO blood type at the sixth biennial examination, the Framingham Heart Study cohort was followed for the occurrence of cardiovascular events for a period of 10 years. A significant association was found between blood type and intermittent claudication, with blood group O showing the lowest rates. Slight but non-significant excesses for certain other CHD events were also found in non-O individuals. Serum cholesterol showed marginally significant but consistent elevations in non-O subjects but the increased risk in non-O individuals was found to occur independently of the known intermittent claudication risk factors. Since the observed relationship between blood type and intermittent claudication occurs independently of the usual atherosclerotic risk factors, blood type, possibly through an effect on clotting, should be considered in the pathogenesis of intermittent claudication.
AB - Following determination of ABO blood type at the sixth biennial examination, the Framingham Heart Study cohort was followed for the occurrence of cardiovascular events for a period of 10 years. A significant association was found between blood type and intermittent claudication, with blood group O showing the lowest rates. Slight but non-significant excesses for certain other CHD events were also found in non-O individuals. Serum cholesterol showed marginally significant but consistent elevations in non-O subjects but the increased risk in non-O individuals was found to occur independently of the known intermittent claudication risk factors. Since the observed relationship between blood type and intermittent claudication occurs independently of the usual atherosclerotic risk factors, blood type, possibly through an effect on clotting, should be considered in the pathogenesis of intermittent claudication.
KW - ABO blood group
KW - Atherosclerosis
KW - Blood clotting
KW - Cardiovascular disease
KW - Epidemiology
KW - Human genetics
KW - Intermittent claudication
UR - http://www.scopus.com/inward/record.url?scp=0017018243&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017018243&partnerID=8YFLogxK
U2 - 10.1016/0021-9150(76)90036-8
DO - 10.1016/0021-9150(76)90036-8
M3 - Article
C2 - 1008914
AN - SCOPUS:0017018243
VL - 25
SP - 311
EP - 318
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2-3
ER -