Absolute and trend accuracy of a new regional oximeter in healthy volunteers during controlled hypoxia

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

BACKGROUND: Traditional patient monitoring may not detect cerebral tissue hypoxia, and typical interventions may not improve tissue oxygenation. Therefore, monitoring cerebral tissue oxygen status with regional oximetry is being increasingly used by anesthesiologists and perfusionists during surgery. In this study, we evaluated absolute and trend accuracy of a new regional oximetry technology in healthy volunteers. METHODS: A near-infrared spectroscopy sensor connected to a regional oximetry system (O3TM, Masimo, Irvine, CA) was placed on the subject's forehead, to provide continuous measurement of regional oxygen saturation (rSo2). Reference blood samples were taken from the radial artery and internal jugular bulb vein, at baseline and after a series of increasingly hypoxic states induced by altering the inspired oxygen concentration while maintaining normocapnic arterial carbon dioxide pressure (Paco2). Absolute and trend accuracy of the regional oximetry system was determined by comparing rSo2 against reference cerebral oxygen saturation (Savo2), that is calculated by combining arterial and venous saturations of oxygen in the blood samples. RESULTS: Twenty-seven subjects were enrolled. Bias (test method mean error), standard deviation of error, standard error of the mean, and root mean square accuracy (ARMS) of rSo2 compared to Savo2 were 0.4%, 4.0%, 0.3%, and 4.0%, respectively. The limits of agreement were 8.4% (95% confidence interval, 7.6%-9.3%) to 7.6% (95% confidence interval, 8.4% to 6.7%). Trend accuracy analysis yielded a relative mean error of 0%, with a standard deviation of 2.1%, a standard error of 0.1%, and an ARMS of 2.1%. Multiple regression analysis showed that age and skin color did not affect the bias (all P < 0.1). CONCLUSIONS: Masimo O3 regional oximetry provided absolute root-mean-squared error of 4% and relative root-mean-squared error of 2.1% in healthy volunteers undergoing controlled hypoxia.

Original languageEnglish (US)
Pages (from-to)1315-1319
Number of pages5
JournalAnesthesia and Analgesia
Volume119
Issue number6
DOIs
StatePublished - Dec 4 2014

Fingerprint

Oximetry
Healthy Volunteers
Oxygen
Confidence Intervals
Skin Pigmentation
Brain Hypoxia
Radial Artery
Forehead
Near-Infrared Spectroscopy
Jugular Veins
Physiologic Monitoring
Carbon Dioxide
Regression Analysis
Hypoxia
Technology
Pressure

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Medicine(all)

Cite this

Absolute and trend accuracy of a new regional oximeter in healthy volunteers during controlled hypoxia. / Redford, Daniel T; Paidy, Samata R; Kashif, Faisal.

In: Anesthesia and Analgesia, Vol. 119, No. 6, 04.12.2014, p. 1315-1319.

Research output: Contribution to journalArticle

@article{921129497f2343bfb1eb0a75050142a3,
title = "Absolute and trend accuracy of a new regional oximeter in healthy volunteers during controlled hypoxia",
abstract = "BACKGROUND: Traditional patient monitoring may not detect cerebral tissue hypoxia, and typical interventions may not improve tissue oxygenation. Therefore, monitoring cerebral tissue oxygen status with regional oximetry is being increasingly used by anesthesiologists and perfusionists during surgery. In this study, we evaluated absolute and trend accuracy of a new regional oximetry technology in healthy volunteers. METHODS: A near-infrared spectroscopy sensor connected to a regional oximetry system (O3TM, Masimo, Irvine, CA) was placed on the subject's forehead, to provide continuous measurement of regional oxygen saturation (rSo2). Reference blood samples were taken from the radial artery and internal jugular bulb vein, at baseline and after a series of increasingly hypoxic states induced by altering the inspired oxygen concentration while maintaining normocapnic arterial carbon dioxide pressure (Paco2). Absolute and trend accuracy of the regional oximetry system was determined by comparing rSo2 against reference cerebral oxygen saturation (Savo2), that is calculated by combining arterial and venous saturations of oxygen in the blood samples. RESULTS: Twenty-seven subjects were enrolled. Bias (test method mean error), standard deviation of error, standard error of the mean, and root mean square accuracy (ARMS) of rSo2 compared to Savo2 were 0.4{\%}, 4.0{\%}, 0.3{\%}, and 4.0{\%}, respectively. The limits of agreement were 8.4{\%} (95{\%} confidence interval, 7.6{\%}-9.3{\%}) to 7.6{\%} (95{\%} confidence interval, 8.4{\%} to 6.7{\%}). Trend accuracy analysis yielded a relative mean error of 0{\%}, with a standard deviation of 2.1{\%}, a standard error of 0.1{\%}, and an ARMS of 2.1{\%}. Multiple regression analysis showed that age and skin color did not affect the bias (all P < 0.1). CONCLUSIONS: Masimo O3 regional oximetry provided absolute root-mean-squared error of 4{\%} and relative root-mean-squared error of 2.1{\%} in healthy volunteers undergoing controlled hypoxia.",
author = "Redford, {Daniel T} and Paidy, {Samata R} and Faisal Kashif",
year = "2014",
month = "12",
day = "4",
doi = "10.1213/ANE.0000000000000474",
language = "English (US)",
volume = "119",
pages = "1315--1319",
journal = "Anesthesia and Analgesia",
issn = "0003-2999",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Absolute and trend accuracy of a new regional oximeter in healthy volunteers during controlled hypoxia

AU - Redford, Daniel T

AU - Paidy, Samata R

AU - Kashif, Faisal

PY - 2014/12/4

Y1 - 2014/12/4

N2 - BACKGROUND: Traditional patient monitoring may not detect cerebral tissue hypoxia, and typical interventions may not improve tissue oxygenation. Therefore, monitoring cerebral tissue oxygen status with regional oximetry is being increasingly used by anesthesiologists and perfusionists during surgery. In this study, we evaluated absolute and trend accuracy of a new regional oximetry technology in healthy volunteers. METHODS: A near-infrared spectroscopy sensor connected to a regional oximetry system (O3TM, Masimo, Irvine, CA) was placed on the subject's forehead, to provide continuous measurement of regional oxygen saturation (rSo2). Reference blood samples were taken from the radial artery and internal jugular bulb vein, at baseline and after a series of increasingly hypoxic states induced by altering the inspired oxygen concentration while maintaining normocapnic arterial carbon dioxide pressure (Paco2). Absolute and trend accuracy of the regional oximetry system was determined by comparing rSo2 against reference cerebral oxygen saturation (Savo2), that is calculated by combining arterial and venous saturations of oxygen in the blood samples. RESULTS: Twenty-seven subjects were enrolled. Bias (test method mean error), standard deviation of error, standard error of the mean, and root mean square accuracy (ARMS) of rSo2 compared to Savo2 were 0.4%, 4.0%, 0.3%, and 4.0%, respectively. The limits of agreement were 8.4% (95% confidence interval, 7.6%-9.3%) to 7.6% (95% confidence interval, 8.4% to 6.7%). Trend accuracy analysis yielded a relative mean error of 0%, with a standard deviation of 2.1%, a standard error of 0.1%, and an ARMS of 2.1%. Multiple regression analysis showed that age and skin color did not affect the bias (all P < 0.1). CONCLUSIONS: Masimo O3 regional oximetry provided absolute root-mean-squared error of 4% and relative root-mean-squared error of 2.1% in healthy volunteers undergoing controlled hypoxia.

AB - BACKGROUND: Traditional patient monitoring may not detect cerebral tissue hypoxia, and typical interventions may not improve tissue oxygenation. Therefore, monitoring cerebral tissue oxygen status with regional oximetry is being increasingly used by anesthesiologists and perfusionists during surgery. In this study, we evaluated absolute and trend accuracy of a new regional oximetry technology in healthy volunteers. METHODS: A near-infrared spectroscopy sensor connected to a regional oximetry system (O3TM, Masimo, Irvine, CA) was placed on the subject's forehead, to provide continuous measurement of regional oxygen saturation (rSo2). Reference blood samples were taken from the radial artery and internal jugular bulb vein, at baseline and after a series of increasingly hypoxic states induced by altering the inspired oxygen concentration while maintaining normocapnic arterial carbon dioxide pressure (Paco2). Absolute and trend accuracy of the regional oximetry system was determined by comparing rSo2 against reference cerebral oxygen saturation (Savo2), that is calculated by combining arterial and venous saturations of oxygen in the blood samples. RESULTS: Twenty-seven subjects were enrolled. Bias (test method mean error), standard deviation of error, standard error of the mean, and root mean square accuracy (ARMS) of rSo2 compared to Savo2 were 0.4%, 4.0%, 0.3%, and 4.0%, respectively. The limits of agreement were 8.4% (95% confidence interval, 7.6%-9.3%) to 7.6% (95% confidence interval, 8.4% to 6.7%). Trend accuracy analysis yielded a relative mean error of 0%, with a standard deviation of 2.1%, a standard error of 0.1%, and an ARMS of 2.1%. Multiple regression analysis showed that age and skin color did not affect the bias (all P < 0.1). CONCLUSIONS: Masimo O3 regional oximetry provided absolute root-mean-squared error of 4% and relative root-mean-squared error of 2.1% in healthy volunteers undergoing controlled hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=84914141399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84914141399&partnerID=8YFLogxK

U2 - 10.1213/ANE.0000000000000474

DO - 10.1213/ANE.0000000000000474

M3 - Article

C2 - 25405692

AN - SCOPUS:84914141399

VL - 119

SP - 1315

EP - 1319

JO - Anesthesia and Analgesia

JF - Anesthesia and Analgesia

SN - 0003-2999

IS - 6

ER -