Absorption and Distribution of Ethanol during altered Portal Dynamics in the Dog

Charles L. Witte, Stanley Asnis, Marlys Hearst Witte, Oscar F. Sterle, Young C. Chung

Research output: Contribution to journalArticle

Abstract

Absorption and distribution of ethyl alcohol was studied in dogs with altered portal blood flow and in control animals. Portal venous obstruction in association with extrahepatic portal hypertension retards absorption of alcohol from the gastrointestinal tract. Hepatic venous outflow obstruction in association with intrahepatic portal hypertension does not appreciably change absorption or distribution of alcohol. End-to-side portacaval shunt does not affect the rate of alcohol absorption but as in dogs with portal vein obstruction decreases extraction by the liver. These findings may be applicable to patients with hepatic cirrhosis who have ingested large quantities of ethanol and continue to do so after portacaval shunt.

Original languageEnglish (US)
Pages (from-to)1288-1293
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume130
Issue number4
DOIs
StatePublished - Apr 1969
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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