Abstract
T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 557-565 |
| Number of pages | 9 |
| Journal | Vaccine |
| Volume | 19 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Oct 15 2000 |
| Externally published | Yes |
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Keywords
- B cells
- Cytokines
- Humoral response
- IL-1
- Pneumococcal vaccine
- Splenectomy
- Thymus independent antigens
- TNP-Ficoll
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)
Cite this
Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines. / Bondada, Subbarao; Wu, Hsin-Jung Joyce; Robertson, Darrell A.; Chelvarajan, Ralph L.
In: Vaccine, Vol. 19, No. 4-5, 15.10.2000, p. 557-565.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines
AU - Bondada, Subbarao
AU - Wu, Hsin-Jung Joyce
AU - Robertson, Darrell A.
AU - Chelvarajan, Ralph L.
PY - 2000/10/15
Y1 - 2000/10/15
N2 - T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.
AB - T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.
KW - B cells
KW - Cytokines
KW - Humoral response
KW - IL-1
KW - Pneumococcal vaccine
KW - Splenectomy
KW - Thymus independent antigens
KW - TNP-Ficoll
UR - http://www.scopus.com/inward/record.url?scp=0034668158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034668158&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(00)00161-4
DO - 10.1016/S0264-410X(00)00161-4
M3 - Article
C2 - 11027821
AN - SCOPUS:0034668158
VL - 19
SP - 557
EP - 565
JO - Vaccine
JF - Vaccine
SN - 0264-410X
IS - 4-5
ER -