Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines

Subbarao Bondada, Hsin Jung Wu, Darrell A. Robertson, Ralph L. Chelvarajan

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged.

Original languageEnglish (US)
Pages (from-to)557-565
Number of pages9
JournalVaccine
Volume19
Issue number4-5
DOIs
StatePublished - Oct 15 2000
Externally publishedYes

Keywords

  • B cells
  • Cytokines
  • Humoral response
  • IL-1
  • Pneumococcal vaccine
  • Splenectomy
  • TNP-Ficoll
  • Thymus independent antigens

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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