Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines

Subbarao Bondada, Hsin-Jung Joyce Wu, Darrell A. Robertson, Ralph L. Chelvarajan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)557-565
Number of pages9
JournalVaccine
Volume19
Issue number4-5
DOIs
StatePublished - Oct 15 2000
Externally publishedYes

Fingerprint

T Independent Antigens
Polysaccharides
neonates
polysaccharides
Vaccines
vaccines
immune response
antigens
Bacterial Polysaccharides
cells
Pneumococcal Vaccines
dendritic cells
Helper-Inducer T-Lymphocytes
Dendritic Cells
Antibody Formation
macrophages
cytokines
T-lymphocytes
Macrophages
Cytokines

Keywords

  • B cells
  • Cytokines
  • Humoral response
  • IL-1
  • Pneumococcal vaccine
  • Splenectomy
  • Thymus independent antigens
  • TNP-Ficoll

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines. / Bondada, Subbarao; Wu, Hsin-Jung Joyce; Robertson, Darrell A.; Chelvarajan, Ralph L.

In: Vaccine, Vol. 19, No. 4-5, 15.10.2000, p. 557-565.

Research output: Contribution to journalArticle

Bondada, Subbarao ; Wu, Hsin-Jung Joyce ; Robertson, Darrell A. ; Chelvarajan, Ralph L. / Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines. In: Vaccine. 2000 ; Vol. 19, No. 4-5. pp. 557-565.
@article{25d95963568b4867b2aa7847500b8c5a,
title = "Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines",
abstract = "T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.",
keywords = "B cells, Cytokines, Humoral response, IL-1, Pneumococcal vaccine, Splenectomy, Thymus independent antigens, TNP-Ficoll",
author = "Subbarao Bondada and Wu, {Hsin-Jung Joyce} and Robertson, {Darrell A.} and Chelvarajan, {Ralph L.}",
year = "2000",
month = "10",
day = "15",
doi = "10.1016/S0264-410X(00)00161-4",
language = "English (US)",
volume = "19",
pages = "557--565",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "4-5",

}

TY - JOUR

T1 - Accessory cell defect in unresponsiveness of neonates and aged to polysaccharide vaccines

AU - Bondada, Subbarao

AU - Wu, Hsin-Jung Joyce

AU - Robertson, Darrell A.

AU - Chelvarajan, Ralph L.

PY - 2000/10/15

Y1 - 2000/10/15

N2 - T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.

AB - T independent antigens elicit antibody responses in the absence of carrier specific T helper cells but require signals from accessory cells (macrophages and dendritic cells) or specific cytokines. They are further subdivided into TI-1 and TI-2 categories based on the ability of TI-1 but not TI-2 antigens to elicit immune responses from neonates. Most bacterial polysaccharides including the pneumococcal polysaccharide vaccines belong to the TI-2 class. It is hypothesized that defects in accessory cell function play a critical role in the failure of neonates to respond to such TI-2 antigens. Immune responses to these TI-2 stimuli are also reduced in the aged, also due to a quantitative deficiency in accessory cells. Agents that can stimulate accessory cell function may provide an alternative strategy to improve the immunogenicity of the polysaccharide vaccines in the neonates and the aged. (C) 2000 Elsevier Science Ltd.

KW - B cells

KW - Cytokines

KW - Humoral response

KW - IL-1

KW - Pneumococcal vaccine

KW - Splenectomy

KW - Thymus independent antigens

KW - TNP-Ficoll

UR - http://www.scopus.com/inward/record.url?scp=0034668158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034668158&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(00)00161-4

DO - 10.1016/S0264-410X(00)00161-4

M3 - Article

C2 - 11027821

AN - SCOPUS:0034668158

VL - 19

SP - 557

EP - 565

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 4-5

ER -