Accommodation: Preventing Injury in Transplantation and Disease

Cody A. Koch, Zain I. Khalpey, Jeffrey L. Platt

Research output: Contribution to journalShort surveypeer-review

100 Scopus citations

Abstract

Humoral immunity, as a cause of damage to blood vessels, poses a major barrier to successful transplantation of organs. Under some conditions, humoral immunity causes little or no damage to an organ graft. We have referred to this condition, in which a vascularized graft functions in the face of humoral immunity directed against it, as "accommodation." In this paper, we review changes in the graft and in the host that may account for accommodation, and we consider that what we call accommodation of organ grafts may occur widely in the context of immune responses, enabling immune responses to target infectious organisms without harming self-tissues.

Original languageEnglish (US)
Pages (from-to)5143-5148
Number of pages6
JournalJournal of Immunology
Volume172
Issue number9
DOIs
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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