Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in ischemic myocardium during acute coronary occlusion and reperfusion

J. A. Bianco, L. A. Pape, Joseph S Alpert, M. Zheng, D. Hnatowich, M. M. Goodman, F. F. Knapp

Research output: Contribution to journalArticle

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Abstract

The myocardial uptake of 15-(p-iodophenyl)-6-tellurapentadecanoic acid (TPDA) was studied in dogs during coronary occlusion and after reperfusion. In 8 dogs with a 3-hour occlusion (Group A) with (n = 5) and without (n = 3) 30 minutes of reperfusion, iodine-125 TPDA uptake correlated well with microsphere myocardial blood flow over a wide range of flow levels (n = 111, r = 0.94). In 6 dogs with a 20-minute occlusion of the left anterior descending coronary artery and 1 hour of reperfusion (Group B), iodine-125 TPDA uptake correlated equally well with myocardial blood flow (n = 37, r = 0.90). There was no difference between the slopes of regression lines for Groups A and B, indicating no release from the myocardium of radioiodinated TPDA. Dual radiolabeling of TPDA was employed in 5 Group A animals by intravenous injection of iodine-125 TPDA during coronary occlusion and iodine-131 TPDA after reperfusion. In 63 myocardial samples, microsphere reperfusion flow and iodine-131 TPDA uptake were closely correlated (r = 0.91). As with monovalent cations, at myocardial flows higher than control flows, iodine-131 TPDA uptake was flow limited. It is concluded that: 1) radioiodinated TPDA accurately reveals severely ischemic areas of myocardium without myocardial release of the radionuclide in coronary occlusions lasting 20 to 180 minutes and followed by reperfusion, and 2) double radiolabeled TPDA allows assessment of both occlusion and reperfusion flows. This compound may find an application in the measurement of infarct size and the evaluation of interventional therapies in acute myocardial infarction.

Original languageEnglish (US)
Pages (from-to)80-87
Number of pages8
JournalJournal of the American College of Cardiology
Volume4
Issue number1
DOIs
StatePublished - 1984
Externally publishedYes

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Myocardial Reperfusion
Coronary Occlusion
Myocardium
Acids
Reperfusion
Iodine
Dogs
Microspheres
Monovalent Cations
Intravenous Injections
Radioisotopes
Coronary Vessels
Myocardial Infarction

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in ischemic myocardium during acute coronary occlusion and reperfusion. / Bianco, J. A.; Pape, L. A.; Alpert, Joseph S; Zheng, M.; Hnatowich, D.; Goodman, M. M.; Knapp, F. F.

In: Journal of the American College of Cardiology, Vol. 4, No. 1, 1984, p. 80-87.

Research output: Contribution to journalArticle

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title = "Accumulation of radioiodinated 15-(p-iodophenyl)-6-tellurapentadecanoic acid in ischemic myocardium during acute coronary occlusion and reperfusion",
abstract = "The myocardial uptake of 15-(p-iodophenyl)-6-tellurapentadecanoic acid (TPDA) was studied in dogs during coronary occlusion and after reperfusion. In 8 dogs with a 3-hour occlusion (Group A) with (n = 5) and without (n = 3) 30 minutes of reperfusion, iodine-125 TPDA uptake correlated well with microsphere myocardial blood flow over a wide range of flow levels (n = 111, r = 0.94). In 6 dogs with a 20-minute occlusion of the left anterior descending coronary artery and 1 hour of reperfusion (Group B), iodine-125 TPDA uptake correlated equally well with myocardial blood flow (n = 37, r = 0.90). There was no difference between the slopes of regression lines for Groups A and B, indicating no release from the myocardium of radioiodinated TPDA. Dual radiolabeling of TPDA was employed in 5 Group A animals by intravenous injection of iodine-125 TPDA during coronary occlusion and iodine-131 TPDA after reperfusion. In 63 myocardial samples, microsphere reperfusion flow and iodine-131 TPDA uptake were closely correlated (r = 0.91). As with monovalent cations, at myocardial flows higher than control flows, iodine-131 TPDA uptake was flow limited. It is concluded that: 1) radioiodinated TPDA accurately reveals severely ischemic areas of myocardium without myocardial release of the radionuclide in coronary occlusions lasting 20 to 180 minutes and followed by reperfusion, and 2) double radiolabeled TPDA allows assessment of both occlusion and reperfusion flows. This compound may find an application in the measurement of infarct size and the evaluation of interventional therapies in acute myocardial infarction.",
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AU - Pape, L. A.

AU - Alpert, Joseph S

AU - Zheng, M.

AU - Hnatowich, D.

AU - Goodman, M. M.

AU - Knapp, F. F.

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N2 - The myocardial uptake of 15-(p-iodophenyl)-6-tellurapentadecanoic acid (TPDA) was studied in dogs during coronary occlusion and after reperfusion. In 8 dogs with a 3-hour occlusion (Group A) with (n = 5) and without (n = 3) 30 minutes of reperfusion, iodine-125 TPDA uptake correlated well with microsphere myocardial blood flow over a wide range of flow levels (n = 111, r = 0.94). In 6 dogs with a 20-minute occlusion of the left anterior descending coronary artery and 1 hour of reperfusion (Group B), iodine-125 TPDA uptake correlated equally well with myocardial blood flow (n = 37, r = 0.90). There was no difference between the slopes of regression lines for Groups A and B, indicating no release from the myocardium of radioiodinated TPDA. Dual radiolabeling of TPDA was employed in 5 Group A animals by intravenous injection of iodine-125 TPDA during coronary occlusion and iodine-131 TPDA after reperfusion. In 63 myocardial samples, microsphere reperfusion flow and iodine-131 TPDA uptake were closely correlated (r = 0.91). As with monovalent cations, at myocardial flows higher than control flows, iodine-131 TPDA uptake was flow limited. It is concluded that: 1) radioiodinated TPDA accurately reveals severely ischemic areas of myocardium without myocardial release of the radionuclide in coronary occlusions lasting 20 to 180 minutes and followed by reperfusion, and 2) double radiolabeled TPDA allows assessment of both occlusion and reperfusion flows. This compound may find an application in the measurement of infarct size and the evaluation of interventional therapies in acute myocardial infarction.

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