Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ

Jie Lei, Zhi Gang Xu, Dian Yong Tang, Yong Li, Jia Xu, Hong Yu Li, Jin Zhu, Zhong Zhu Chen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalACS Combinatorial Science
Volume20
Issue number5
DOIs
StatePublished - May 14 2018
Externally publishedYes

Keywords

  • 6-methylpyrazin-2(1 H)-one
  • allene
  • multicomponent reaction (MCR)
  • substituted furans
  • Ugi reaction

ASJC Scopus subject areas

  • Chemistry(all)

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