Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ

Jie Lei, Zhi Gang Xu, Dian Yong Tang, Yong Li, Jia Xu, Hong Yu Li, Jin Zhu, Zhong Zhu Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Under the acidic conditions, substituted furans were constructed from γ-alkynyl ketones through corresponding allene intermediates in one-pot. The methodology was also tailored to a series of the Ugi reaction products for the synthesis of 6-methylpyrazin-2(1H)-one derivatives. The current method offered significant advantages for the combinatorial applications of these chemical scaffolds.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalACS Combinatorial Science
Volume20
Issue number5
DOIs
StatePublished - May 14 2018
Externally publishedYes

Fingerprint

Furans
Ketones
Reaction products
Scaffolds
Derivatives
Acids
propadiene
furan

Keywords

  • 6-methylpyrazin-2(1 H)-one
  • allene
  • multicomponent reaction (MCR)
  • substituted furans
  • Ugi reaction

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ. / Lei, Jie; Xu, Zhi Gang; Tang, Dian Yong; Li, Yong; Xu, Jia; Li, Hong Yu; Zhu, Jin; Chen, Zhong Zhu.

In: ACS Combinatorial Science, Vol. 20, No. 5, 14.05.2018, p. 292-297.

Research output: Contribution to journalArticle

Lei, Jie ; Xu, Zhi Gang ; Tang, Dian Yong ; Li, Yong ; Xu, Jia ; Li, Hong Yu ; Zhu, Jin ; Chen, Zhong Zhu. / Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1 H)-one Derivatives via Allene Intermediate Formed in Situ. In: ACS Combinatorial Science. 2018 ; Vol. 20, No. 5. pp. 292-297.
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