Acoustic response of targeted nanodroplets post-activation using high frame rate imaging

Ge Zhang, Shengtao Lin, Chee Hau Leow, Kuin Pang, Javier Hernandez-Gil, Melisse Chee, Nicholas J. Long, Terry O Matsunaga, Meng Xing Tang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

Targeted phase-change contrast agents (PCCAs) have shown great potential for both cancer imaging and therapy. However the acoustic response of targeted PCCAs exposed to ultrasound high frame rate imaging pulses after vaporization has not been fully explored. We herein report the investigation of the change in acoustic signal of folate receptor targeted (FR)-and non-targeted (NT)-PCCAs exposed to breast cancer cells immediately after acoustic vaporization using high frame rate ultrasound imaging. The results show that the vaporized FR-PCCAs measured on the cells has higher acoustic signal than vaporized NT-PCCAs. Moreover, it was found that the acoustic signal of vaporized FR-PCCA on the cells is more persistent than that of vaporized NT-PCCAs 1 second post activation. This is likely because the FR-PCCAs can be vaporized and remain attached to the cancer cells. Furthermore, the high frame rate ultrasound imaging used in this study showed the fast decay of the acoustic signal on the cells immediately after activation, particularly for the NT-PCCAs. These results offer a new insight into the behavior of targeted PCCAs for ultrasound molecular imaging and therapy.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period9/6/179/9/17

Keywords

  • Acoustic Vaporization
  • Breast Cancer Cells
  • Cancer Molecular Imaging
  • Targeted Phase-Change Contrast Agents
  • Ultrafast Imaging

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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