Acoustoelectric imaging for beat-to-beat cardiac activation wave mapping in an in vivo swine model

Alexander Alvarez, Chet Preston, Teodoro Trujillo, Russell S. Witte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac ventricular arrhythmias - electrical activation abnormalities that can result in sudden cardiac death - are difficult to manage with ablative treatment as many have complex, non-sustained 4D (volume over time) activation patterns that cannot be fully captured by existing electroanatomic mapping systems. In this study, we describe the use of acoustoelectric cardiac imaging (ACI) for high resolution, beat-to-beat mapping of electrical dynamics in an in vivo swine model. Beat-to-beat variability was tracked in the swine; the variation in the peak magnitude, peak myocardial location, peak time, and SNR across 20 beats were measured as 5.27 ± 0.68 µV, 3.32 ± 0.41 mm from the epicardium, -2.73 ± 0.38 ms from the peak EGM, and 25.3 ± 8.1 dB, respectively. Additionally, propagation velocity was tracked across four pigs and was calculated as 0.153 ± 0.108 m/s along the endocardial-epicardial axis and 0.123 ± 0.098 m/s along the apicobasal axis. This study suggests that ACI has the potential to improve ablation treatment of arrhythmias through higher resolution, beat-to-beat pre-ablation mapping and characterization of ventricular arrhythmias.

Original languageEnglish (US)
Title of host publicationIUS 2020 - International Ultrasonics Symposium, Proceedings
PublisherIEEE Computer Society
ISBN (Electronic)9781728154480
DOIs
StatePublished - Sep 7 2020
Event2020 IEEE International Ultrasonics Symposium, IUS 2020 - Las Vegas, United States
Duration: Sep 7 2020Sep 11 2020

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2020-September
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2020 IEEE International Ultrasonics Symposium, IUS 2020
CountryUnited States
CityLas Vegas
Period9/7/209/11/20

Keywords

  • Arrhythmia
  • Electroanatomic mapping
  • Electrocardiography
  • Isochrone

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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