Acoustoelectric imaging of time-varying current produced by a clinical deep brain stimulator

Chet Preston, Yexian Qin, Pier Ingram, Willard Kassof, Alex Burton, Russell S Witte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Deep brain stimulation (DBS) is an effective treatment for a variety of brain disorders, including Parkinson's disease, depression and chronic pain. However, there is no reliable method to non-invasively image electric current flow generated by a DBS. In this study, we demonstrate 4D current source density imaging based on the acoustoelectric (AE) effect, which integrates an ultrasound beam with electrical recording, to map current flow produced by a clinical DBS device. AE imaging was able to accurately determine the polarity, magnitude and location of the current densities near the DBS device placed in physiologic saline with a signal-to-noise ratio of 17.1 dB using stimulation parameters similar to what are used on patients. Pulse echo (PE) ultrasound was acquired simultaneously to provide additional information regarding the spatial coordinates and structure of the DBS without need of additional techniques. These results suggest that AE imaging combined with PE ultrasound may provide valuable feedback during and after implantation of a DBS device.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period9/6/179/9/17

Keywords

  • Brain Implant Current Source Densities
  • Elecrical Brain Mapping
  • Electrical Impedance Imaging
  • Parkinson's Disease
  • Ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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