Acrylamide: Dermal exposure produces genetic damage in male mouse germ cells

Gustavo A. Gutierrez-Espeleta, Lori A. Hughes, Walter W Piegorsch, Michael D. Shelby, Walderico M. Generoso

Research output: Contribution to journalArticle

Abstract

Acrylamide is used extensively in sewage and wastewater treatment plants, in the paper and pulp industry, in treatment of potable water, and in research laboratories for chromatography, electrophoresis, and electron microscopy. Dermal contact is a major route of human exposure. It has been shown that acrylamide is highly effective in breaking chromosomes of germ cells of male mice and rats when administered intraperitoneally or orally, resulting both in the early death of conceptuses and in the transmission of reciprocal translocations to live-born progeny. It is now reported that acrylamide is absorbed through the skin of male mice, reaches the germ cells, and induces chromosomal damage. The magnitude of genetic damage appears to be proportional to the dose administered topically.

Original languageEnglish (US)
Pages (from-to)189-192
Number of pages4
JournalFundamental and Applied Toxicology
Volume18
Issue number2
DOIs
StatePublished - 1992
Externally publishedYes

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Acrylamide
Germ Cells
Cells
Skin
Sewage treatment
Paper and pulp industry
Water Purification
Research laboratories
Chromosomes
Waste Water
Sewage
Chromatography
Electrophoresis
Drinking Water
Wastewater treatment
Electron microscopy
Rats
Electron Microscopy
Industry
Research

ASJC Scopus subject areas

  • Toxicology

Cite this

Acrylamide : Dermal exposure produces genetic damage in male mouse germ cells. / Gutierrez-Espeleta, Gustavo A.; Hughes, Lori A.; Piegorsch, Walter W; Shelby, Michael D.; Generoso, Walderico M.

In: Fundamental and Applied Toxicology, Vol. 18, No. 2, 1992, p. 189-192.

Research output: Contribution to journalArticle

Gutierrez-Espeleta, Gustavo A. ; Hughes, Lori A. ; Piegorsch, Walter W ; Shelby, Michael D. ; Generoso, Walderico M. / Acrylamide : Dermal exposure produces genetic damage in male mouse germ cells. In: Fundamental and Applied Toxicology. 1992 ; Vol. 18, No. 2. pp. 189-192.
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