Actinic damage in histopathologically normal skin

Peter H. Bartels, Robert S Krouse, Anil P Rama Rao, Michael Yozwiak, Yun Liu, Hubert G. Bartels, David S. Alberts

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


OBJECTIVE: To establish measures of sun damage in histopathologically normal skin. STUDY DESIGN: Biopsies were taken from the upper inner arm, representing skin with presumably minimum sun exposure, from skin of the forearm with no visible sun damage, from skin of the forearm with visible sun damage and from normal-appearing skin from the forearm of individuals who had sun exposure that had resulted in actinic keratosis (AK) lesions. In addition, a data set of nuclei from AKs was recorded. RESULTS: In histopathologically normal skin, monotonically increasing damage was observed in individuals with increased exposure to solar radiation. CONCLUSION: Karyometry can detect and statistically secure changes in skin due to solar exposure at a stage at which the skin is histopathologically determined to be normal.

Original languageEnglish (US)
Pages (from-to)316-322
Number of pages7
JournalAnalytical and Quantitative Cytology and Histology
Issue number6
StatePublished - Dec 2008


  • Actinic keratosis
  • Histopathologically normal skin
  • Karyometry
  • Sun damage

ASJC Scopus subject areas

  • Anatomy
  • Histology


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