Activation of bovine factor XII (hageman factor) by plasma kallikrein

Kazuo Fujikawa, Ronald L Heimark, Kotoku Kurachi, Earl W. Davie

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Bovine factor XII is a single-chain plasma protein that is involved in the early or contact phase of blood coagulation. In the reactions leading to fibrin formation, it is converted to factor XIIa, a serine protease composed of a heavy chain and a light chain held together by a disulfide bond(s). The activation of factor XII is catalyzed by plasma kallikrein which cleaves a single internal arginyl-valine peptide bond in the precursor protein. The activation reaction also requires the presence of a lipid component, such as sulfatide, ganglioside, or stearic acid. Kaolin, in the presence of high molecular weight kininogen, or dextran sulfate can provide a nonphysiological contact surface in this reaction. Other materials from bovine sources, including brain galactoceramide, sphin-gomyelin, phosphatidylcholine, cephalin, aorta proteoglycan, cornea keratan sulfate, vitreous humor hyaluronic acid, submaxillary mucin, and calf skin collagen, were inactive in the activation of factor XII by kallikrein. Factor XIa and plasmin also activated factor XII in the presence of sulfatide but were only 40 and 20% as active as kallikrein, respectively. Other clotting enzymes, including factor IXa, factor Xa, or thrombin, showed no activity in this reaction. The effect of sulfatide on reducing the clotting time of plasma suggests that some lipids, such as sulfatide, may be of importance in the initiation of the coagulation process, while others, such as phospholipids, play an important role in the intermediate phase of blood clotting.

Original languageEnglish (US)
Pages (from-to)1322-1330
Number of pages9
JournalBiochemistry
Volume19
Issue number7
StatePublished - 1980
Externally publishedYes

Fingerprint

Plasma Kallikrein
Sulfoglycosphingolipids
Factor XII
Factor XIIa
Chemical activation
Kallikreins
Blood Coagulation
Coagulation
arginylvaline
Blood
Factor XIa
Factor IXa
High Molecular Weight Kininogens
Phosphatidylethanolamines
Keratan Sulfate
Lipids
Kaolin
Vitreous Body
Dextran Sulfate
Factor Xa

ASJC Scopus subject areas

  • Biochemistry

Cite this

Fujikawa, K., Heimark, R. L., Kurachi, K., & Davie, E. W. (1980). Activation of bovine factor XII (hageman factor) by plasma kallikrein. Biochemistry, 19(7), 1322-1330.

Activation of bovine factor XII (hageman factor) by plasma kallikrein. / Fujikawa, Kazuo; Heimark, Ronald L; Kurachi, Kotoku; Davie, Earl W.

In: Biochemistry, Vol. 19, No. 7, 1980, p. 1322-1330.

Research output: Contribution to journalArticle

Fujikawa, K, Heimark, RL, Kurachi, K & Davie, EW 1980, 'Activation of bovine factor XII (hageman factor) by plasma kallikrein', Biochemistry, vol. 19, no. 7, pp. 1322-1330.
Fujikawa, Kazuo ; Heimark, Ronald L ; Kurachi, Kotoku ; Davie, Earl W. / Activation of bovine factor XII (hageman factor) by plasma kallikrein. In: Biochemistry. 1980 ; Vol. 19, No. 7. pp. 1322-1330.
@article{6c448e466bd14fb280dfdbc5e815c2fd,
title = "Activation of bovine factor XII (hageman factor) by plasma kallikrein",
abstract = "Bovine factor XII is a single-chain plasma protein that is involved in the early or contact phase of blood coagulation. In the reactions leading to fibrin formation, it is converted to factor XIIa, a serine protease composed of a heavy chain and a light chain held together by a disulfide bond(s). The activation of factor XII is catalyzed by plasma kallikrein which cleaves a single internal arginyl-valine peptide bond in the precursor protein. The activation reaction also requires the presence of a lipid component, such as sulfatide, ganglioside, or stearic acid. Kaolin, in the presence of high molecular weight kininogen, or dextran sulfate can provide a nonphysiological contact surface in this reaction. Other materials from bovine sources, including brain galactoceramide, sphin-gomyelin, phosphatidylcholine, cephalin, aorta proteoglycan, cornea keratan sulfate, vitreous humor hyaluronic acid, submaxillary mucin, and calf skin collagen, were inactive in the activation of factor XII by kallikrein. Factor XIa and plasmin also activated factor XII in the presence of sulfatide but were only 40 and 20{\%} as active as kallikrein, respectively. Other clotting enzymes, including factor IXa, factor Xa, or thrombin, showed no activity in this reaction. The effect of sulfatide on reducing the clotting time of plasma suggests that some lipids, such as sulfatide, may be of importance in the initiation of the coagulation process, while others, such as phospholipids, play an important role in the intermediate phase of blood clotting.",
author = "Kazuo Fujikawa and Heimark, {Ronald L} and Kotoku Kurachi and Davie, {Earl W.}",
year = "1980",
language = "English (US)",
volume = "19",
pages = "1322--1330",
journal = "Biochemistry",
issn = "0006-2960",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Activation of bovine factor XII (hageman factor) by plasma kallikrein

AU - Fujikawa, Kazuo

AU - Heimark, Ronald L

AU - Kurachi, Kotoku

AU - Davie, Earl W.

PY - 1980

Y1 - 1980

N2 - Bovine factor XII is a single-chain plasma protein that is involved in the early or contact phase of blood coagulation. In the reactions leading to fibrin formation, it is converted to factor XIIa, a serine protease composed of a heavy chain and a light chain held together by a disulfide bond(s). The activation of factor XII is catalyzed by plasma kallikrein which cleaves a single internal arginyl-valine peptide bond in the precursor protein. The activation reaction also requires the presence of a lipid component, such as sulfatide, ganglioside, or stearic acid. Kaolin, in the presence of high molecular weight kininogen, or dextran sulfate can provide a nonphysiological contact surface in this reaction. Other materials from bovine sources, including brain galactoceramide, sphin-gomyelin, phosphatidylcholine, cephalin, aorta proteoglycan, cornea keratan sulfate, vitreous humor hyaluronic acid, submaxillary mucin, and calf skin collagen, were inactive in the activation of factor XII by kallikrein. Factor XIa and plasmin also activated factor XII in the presence of sulfatide but were only 40 and 20% as active as kallikrein, respectively. Other clotting enzymes, including factor IXa, factor Xa, or thrombin, showed no activity in this reaction. The effect of sulfatide on reducing the clotting time of plasma suggests that some lipids, such as sulfatide, may be of importance in the initiation of the coagulation process, while others, such as phospholipids, play an important role in the intermediate phase of blood clotting.

AB - Bovine factor XII is a single-chain plasma protein that is involved in the early or contact phase of blood coagulation. In the reactions leading to fibrin formation, it is converted to factor XIIa, a serine protease composed of a heavy chain and a light chain held together by a disulfide bond(s). The activation of factor XII is catalyzed by plasma kallikrein which cleaves a single internal arginyl-valine peptide bond in the precursor protein. The activation reaction also requires the presence of a lipid component, such as sulfatide, ganglioside, or stearic acid. Kaolin, in the presence of high molecular weight kininogen, or dextran sulfate can provide a nonphysiological contact surface in this reaction. Other materials from bovine sources, including brain galactoceramide, sphin-gomyelin, phosphatidylcholine, cephalin, aorta proteoglycan, cornea keratan sulfate, vitreous humor hyaluronic acid, submaxillary mucin, and calf skin collagen, were inactive in the activation of factor XII by kallikrein. Factor XIa and plasmin also activated factor XII in the presence of sulfatide but were only 40 and 20% as active as kallikrein, respectively. Other clotting enzymes, including factor IXa, factor Xa, or thrombin, showed no activity in this reaction. The effect of sulfatide on reducing the clotting time of plasma suggests that some lipids, such as sulfatide, may be of importance in the initiation of the coagulation process, while others, such as phospholipids, play an important role in the intermediate phase of blood clotting.

UR - http://www.scopus.com/inward/record.url?scp=0019311044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019311044&partnerID=8YFLogxK

M3 - Article

C2 - 6155941

AN - SCOPUS:0019311044

VL - 19

SP - 1322

EP - 1330

JO - Biochemistry

JF - Biochemistry

SN - 0006-2960

IS - 7

ER -