Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment

S. C. Johnson, T. W. Schmitz, C. H. Moritz, M. E. Meyerand, H. A. Rowley, A. L. Alexander, K. W. Hansen, C. E. Gleason, C. M. Carlsson, M. L. Ries, S. Asthana, K. Chen, E. M. Reiman, Gene E Alexander

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

This study examined the functionality of the medial temporal lobe (MTL) and posterior cingulate (PC) in mild cognitive impairment amnestic type (MCI), a syndrome that puts patients at greater risk for developing Alzheimer disease (AD). Functional MRI (fMRI) was used to identify regions normally active during encoding of novel items and recognition of previously learned items in a reference group of 77 healthy young and middle-aged adults. The pattern of activation in this group guided further comparisons between 14 MCI subjects and 14 age-matched controls. The MCI patients exhibited less activity in the PC during recognition of previously learned items, and in the right hippocampus during encoding of novel items, despite comparable task performance to the controls. Reduced fMRI signal change in the MTL supports prior studies implicating the hippocampus for encoding new information. Reduced signal change in the PC converges with recent research on its role in recognition in normal adults as well as metabolic decline in people with genetic or cognitive risk for AD. Our results suggest that a change in function in the PC may account, in part, for memory recollection failure in AD.

Original languageEnglish (US)
Pages (from-to)1604-1612
Number of pages9
JournalNeurobiology of Aging
Volume27
Issue number11
DOIs
StatePublished - Nov 2006

Fingerprint

Gyrus Cinguli
Alzheimer Disease
Brain
Temporal Lobe
Hippocampus
Magnetic Resonance Imaging
Task Performance and Analysis
Cognitive Dysfunction
Research
Recognition (Psychology)

Keywords

  • fMRI
  • Hippocampus
  • Memory
  • Mild cognitive impairment
  • Posterior cingulate

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Activation of brain regions vulnerable to Alzheimer's disease : The effect of mild cognitive impairment. / Johnson, S. C.; Schmitz, T. W.; Moritz, C. H.; Meyerand, M. E.; Rowley, H. A.; Alexander, A. L.; Hansen, K. W.; Gleason, C. E.; Carlsson, C. M.; Ries, M. L.; Asthana, S.; Chen, K.; Reiman, E. M.; Alexander, Gene E.

In: Neurobiology of Aging, Vol. 27, No. 11, 11.2006, p. 1604-1612.

Research output: Contribution to journalArticle

Johnson, SC, Schmitz, TW, Moritz, CH, Meyerand, ME, Rowley, HA, Alexander, AL, Hansen, KW, Gleason, CE, Carlsson, CM, Ries, ML, Asthana, S, Chen, K, Reiman, EM & Alexander, GE 2006, 'Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment', Neurobiology of Aging, vol. 27, no. 11, pp. 1604-1612. https://doi.org/10.1016/j.neurobiolaging.2005.09.017
Johnson, S. C. ; Schmitz, T. W. ; Moritz, C. H. ; Meyerand, M. E. ; Rowley, H. A. ; Alexander, A. L. ; Hansen, K. W. ; Gleason, C. E. ; Carlsson, C. M. ; Ries, M. L. ; Asthana, S. ; Chen, K. ; Reiman, E. M. ; Alexander, Gene E. / Activation of brain regions vulnerable to Alzheimer's disease : The effect of mild cognitive impairment. In: Neurobiology of Aging. 2006 ; Vol. 27, No. 11. pp. 1604-1612.
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