Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia

Prisca Honoré, Elizabeth H. Kamp, Scott D. Rogers, G. F. Gebhart, Patrick W Mantyh

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Spinal lamina I neurons expressing the substance P receptor (SPR) have been shown to play a role in the transmission of somatic inflammatory and neuropathic pain. To evaluate their involvement in visceral nociception in both the noninflamed and inflamed colon, we examined the expression and ligand-induced internalization of the SPR in the rat spinal cord after distention of the noninflamed colon and in rats with inflammation induced by intracolonic instillation of zymosan (3 hours). In the noninflamed animal, acute noxious but not non-noxious colorectal distention induced SPR internalization in lamina I neurons at the thoracolumbar (T13) and lumbosacral (S1) spinal levels, whereas SPR internalization was not detected in lamina I neurons at spinal lumbar segment L4. Although zymosan-induced colorectal inflammation alone did not induce SPR internalization in lamina I neurons, there was an increased number of SPR-expressing lamina I neurons showing SPR internalization in segments T12 through S2 of the spinal cord after colorectal distention. These results show that acute noxious visceral stimuli induce activation of spinal lamina I neurons expressing the SPR and, that after visceral inflammation, there is a marked increase in both the number and rostrocaudal extent of lamina I SPR neurons activated in response to both normally non-noxious and noxious distention of the colon.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalJournal of Pain
Volume3
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Neurokinin-1 Receptors
Nociception
Hyperalgesia
Spinal Cord
Neurons
Colon
Zymosan
Inflammation
Nociceptive Pain
Spinal Cord Dorsal Horn
Neuralgia
Ligands

Keywords

  • Colorectal distention
  • Internalization
  • Neurokinin-1 receptor
  • Spinal cord
  • Visceral pain
  • Zymosan

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia. / Honoré, Prisca; Kamp, Elizabeth H.; Rogers, Scott D.; Gebhart, G. F.; Mantyh, Patrick W.

In: Journal of Pain, Vol. 3, No. 1, 2002, p. 3-11.

Research output: Contribution to journalArticle

Honoré, Prisca ; Kamp, Elizabeth H. ; Rogers, Scott D. ; Gebhart, G. F. ; Mantyh, Patrick W. / Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia. In: Journal of Pain. 2002 ; Vol. 3, No. 1. pp. 3-11.
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