Activation of the A10 mesolimbic system by the σ-receptor agonist (+)SKF 10,047 can be blocked by rimcazole, a novel putative antipsychotic

Angelo Ceci, Melinda Smith, Edward D. French

Research output: Contribution to journalArticlepeer-review

82 Scopus citations

Abstract

This study evaluated with electrophysiological and behavioral techniques the ability of rimcazole, a novel putative antipsychotic and selective σ-receptor ligand, to antagonize the stimulation of the mesocorticolimbic dopamine system by the σ-agonist, (+)SKF 10,047. Rimcazole effectively blocked the (+)SKF 10,047-induced excitation of ventral tegmental dopamine neurons while having no effect on either spontaneous activity or apomorphine-elicited slowing of A10 firing. Rimcazole also antagonized the behavioral hyperactivity produced by (+)SKF 10,047, but not by d-amphetamine which is also mediated through the same mesolimbic dopamine pathway. These data provide further evidence that rimcazole's novel pharmacologic profile may involve a blockade of σ-receptors on mesocorticolimbic dopamine neurons.

Original languageEnglish (US)
Pages (from-to)53-57
Number of pages5
JournalEuropean Journal of Pharmacology
Volume154
Issue number1
DOIs
StatePublished - Sep 1 1988

Keywords

  • A10 dopamine neurons
  • Locomotor behavior
  • Rimcazole
  • SKF 10,047 (N-allylnormetazocine)
  • σ Receptors

ASJC Scopus subject areas

  • Pharmacology

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