Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.

Carlos Jiménez-Romero, Eduardo Ortega-Barría, A. Elizabeth Arnold, Luis Cubilla-Rios

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.

Original languageEnglish (US)
Pages (from-to)700-703
Number of pages4
JournalPharmaceutical Biology
Volume46
Issue number10-11
DOIs
StatePublished - Oct 2008

Keywords

  • Antiplasmodial
  • Endophytic fungus
  • Phomalactone
  • Plasmodium falciparum
  • Xylaria sp.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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