Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.

Carlos Jiménez-Romero, Eduardo Ortega-Barría, A. Elizabeth Arnold, Luis Cubilla-Rios

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.

Original languageEnglish (US)
Pages (from-to)700-703
Number of pages4
JournalPharmaceutical Biology
Volume46
Issue number10-11
DOIs
StatePublished - Oct 1 2008

Keywords

  • Antiplasmodial
  • Endophytic fungus
  • Phomalactone
  • Plasmodium falciparum
  • Xylaria sp.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

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