Activity of cilofungin against coccidioides immitis: Differential in vitro effects on mycelia and spherules correlated with in vivo studies

John N Galgiani, Sung H. Sun, Karl V. Clemons, David A. Stevens

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Cilofungin, a new antifungal drug, was found to inhibit mycelial growth of Coccidioides immitis. Light and electron microscopic observations indicated delay in development of the outer hyphal wall. Cilofungin also blocked incorporation of the chitin substrate, N-acetylglucosamine, into mycelia. However, when C. immitis was grown under conditions that induced spherule development, drug effects were dramatically decreased. Furthermore, efficacy of cilofungin in treatment of murine coccidioidomycosis could not be demonstrated. These studies indicate that glucansynthase inhibitors have activity against C. immitis, and other compounds with different pharmacologic properties or in combination with other antifungal drugs may exploit this biologic effect.

Original languageEnglish (US)
Pages (from-to)944-948
Number of pages5
JournalJournal of Infectious Diseases
Volume162
Issue number4
StatePublished - Oct 1990

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cilofungin
Coccidioides
Mycelium
Pharmaceutical Preparations
Coccidioidomycosis
Chitin
Acetylglucosamine
Electrons
Light
Growth
In Vitro Techniques

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Activity of cilofungin against coccidioides immitis : Differential in vitro effects on mycelia and spherules correlated with in vivo studies. / Galgiani, John N; Sun, Sung H.; Clemons, Karl V.; Stevens, David A.

In: Journal of Infectious Diseases, Vol. 162, No. 4, 10.1990, p. 944-948.

Research output: Contribution to journalArticle

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