Activity of parthenolide at 5HT(2A) receptors

John T. Weber, Mary-Frances O'Connor, Kenneth Hayataka, Nancy Colson, Rustem Medora, Ethan B. Russo, Keith K. Parker

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Parthenolide displaces [3H]ketanserin from 5HT(2A) receptors from rat and rabbit brain and cloned 5HT(2A) receptors. K(i)'s are in the 100-250 μM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT(2A) receptor affinity.

Original languageEnglish (US)
Pages (from-to)651-653
Number of pages3
JournalJournal of Natural Products
Volume60
Issue number6
DOIs
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Ketanserin
receptors
Rats
Brain
Rabbits
antagonists
mechanism of action
rabbits
brain
parthenolide
rats

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Weber, J. T., O'Connor, M-F., Hayataka, K., Colson, N., Medora, R., Russo, E. B., & Parker, K. K. (1997). Activity of parthenolide at 5HT(2A) receptors. Journal of Natural Products, 60(6), 651-653. https://doi.org/10.1021/np960644d

Activity of parthenolide at 5HT(2A) receptors. / Weber, John T.; O'Connor, Mary-Frances; Hayataka, Kenneth; Colson, Nancy; Medora, Rustem; Russo, Ethan B.; Parker, Keith K.

In: Journal of Natural Products, Vol. 60, No. 6, 06.1997, p. 651-653.

Research output: Contribution to journalArticle

Weber, JT, O'Connor, M-F, Hayataka, K, Colson, N, Medora, R, Russo, EB & Parker, KK 1997, 'Activity of parthenolide at 5HT(2A) receptors', Journal of Natural Products, vol. 60, no. 6, pp. 651-653. https://doi.org/10.1021/np960644d
Weber JT, O'Connor M-F, Hayataka K, Colson N, Medora R, Russo EB et al. Activity of parthenolide at 5HT(2A) receptors. Journal of Natural Products. 1997 Jun;60(6):651-653. https://doi.org/10.1021/np960644d
Weber, John T. ; O'Connor, Mary-Frances ; Hayataka, Kenneth ; Colson, Nancy ; Medora, Rustem ; Russo, Ethan B. ; Parker, Keith K. / Activity of parthenolide at 5HT(2A) receptors. In: Journal of Natural Products. 1997 ; Vol. 60, No. 6. pp. 651-653.
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