Activity of parthenolide at 5HT(2A) receptors

John T. Weber, Mary Frances O'Connor, Kenneth Hayataka, Nancy Colson, Rustem Medora, Ethan B. Russo, Keith K. Parker

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Parthenolide displaces [3H]ketanserin from 5HT(2A) receptors from rat and rabbit brain and cloned 5HT(2A) receptors. K(i)'s are in the 100-250 μM range. These results suggest that parthenolide may be a low-affinity antagonist at 5HT receptors; it is unlikely that the entire mechanism of action can be explained by its modest 5HT(2A) receptor affinity.

Original languageEnglish (US)
Pages (from-to)651-653
Number of pages3
JournalJournal Of Natural Products
Volume60
Issue number6
DOIs
StatePublished - Jun 1 1997

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Weber, J. T., O'Connor, M. F., Hayataka, K., Colson, N., Medora, R., Russo, E. B., & Parker, K. K. (1997). Activity of parthenolide at 5HT(2A) receptors. Journal Of Natural Products, 60(6), 651-653. https://doi.org/10.1021/np960644d