Activity of T-type calcium channels is independent of CRMP2 in sensory neurons

Song Cai, Zhiming Shan, Zhongjun Zhang, Aubin Moutal, Rajesh Khanna

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Amongst the regulators of voltage-gated ion channels is the collapsin response mediator protein 2 (CRMP2). CRMP2 regulation of the activity and trafficking of NaV1.7 voltage-gated sodium channels as well as the N-type (CaV2.2) voltage-gated calcium channel (VGCC) has been reported. On the other hand, CRMP2 does not appear to regulate L- (CaV1.x), P/Q- (CaV2.1), and R- (CaV2.3) type high VGCCs. Whether CRMP2 regulates low VGCCs remains an open question. Here, we asked if CRMP2 could regulate the low voltage-gated (T-type/CaV3.x) channels in sensory neurons. Reducing CRMP2 protein levels with short interfering RNAs yielded no change in macroscopic currents carried by T-type channels. No change in biophysical properties of the T-type currents was noted. Future studies pursuing CRMP2 druggability in neuropathic pain will benefit from the findings that CRMP2 regulates only the N-type (CaV2.2) calcium channels.

Original languageEnglish (US)
Pages (from-to)147-152
Number of pages6
JournalChannels
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Keywords

  • CRMP2
  • DRG sensory neuron
  • T-type calcium channel
  • electrophysiology

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

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