Acupuncture for depression: A randomized controlled trial

John JB Allen, Rosa N. Schnyer, Andrea S. Chambers, Sabrina K. Hitt, Francisco Moreno, Rachel Manber

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objective: To assess the efficacy of acupuncture as an intervention for major depressive disorder (MDD). Method: Acupuncture was examined in 151 patients with MDD (DSM-IV) who were randomly assigned to 1 of 3 groups in a double-blind randomized controlled trial. The specific intervention involved Traditional Chinese Medicine (TCM)-style acupuncture with manual stimulation for depression; the control conditions consisted of (1) a nonspecific intervention using a comparable number of legitimate acupuncture points not specifically targeted to depressive symptoms and (2) a waitlist condition, which involved waiting without intervention for 8 weeks. After 8 weeks, all patients received the depression-specific acupuncture. Each 8-week intervention regimen consisted of 12 acupuncture sessions delivered in an acupuncturist's office in the community. The primary outcome measure was the 17-item Hamilton Rating Scale for Depression. The study was conducted from February 1998 to April 2002. Results: Twenty patients terminated treatment before the completion of the 8-week intervention (13%) but not differentially by study group. Random regression models of the intent-to-treat sample revealed that although patients receiving acupuncture improved more than those awaiting intervention, no evidence of differential efficacy of the depression-specific over nonspecific intervention was found. Response rates in acupuncture-treated patients were relatively low after 8 weeks (22% and 39% for specific and nonspecific intervention groups, respectively), with the response rate after the entire 16-week trial reaching 50%. Conclusion: Although TCM manual acupuncture is a well-tolerated intervention, results fail to support its efficacy as a monotherapy for MDD. It can't be ruled out that factors unique to the implementation of acupuncture in this research study may have limited the efficacy of interventions compared to those provided in naturalistic settings.

Original languageEnglish (US)
Pages (from-to)1665-1673
Number of pages9
JournalJournal of Clinical Psychiatry
Volume67
Issue number11
StatePublished - Nov 2006

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Acupuncture
Randomized Controlled Trials
Depression
Major Depressive Disorder
Chinese Traditional Medicine
Acupuncture Points
Diagnostic and Statistical Manual of Mental Disorders
Outcome Assessment (Health Care)
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Allen, J. JB., Schnyer, R. N., Chambers, A. S., Hitt, S. K., Moreno, F., & Manber, R. (2006). Acupuncture for depression: A randomized controlled trial. Journal of Clinical Psychiatry, 67(11), 1665-1673.

Acupuncture for depression : A randomized controlled trial. / Allen, John JB; Schnyer, Rosa N.; Chambers, Andrea S.; Hitt, Sabrina K.; Moreno, Francisco; Manber, Rachel.

In: Journal of Clinical Psychiatry, Vol. 67, No. 11, 11.2006, p. 1665-1673.

Research output: Contribution to journalArticle

Allen, JJB, Schnyer, RN, Chambers, AS, Hitt, SK, Moreno, F & Manber, R 2006, 'Acupuncture for depression: A randomized controlled trial', Journal of Clinical Psychiatry, vol. 67, no. 11, pp. 1665-1673.
Allen JJB, Schnyer RN, Chambers AS, Hitt SK, Moreno F, Manber R. Acupuncture for depression: A randomized controlled trial. Journal of Clinical Psychiatry. 2006 Nov;67(11):1665-1673.
Allen, John JB ; Schnyer, Rosa N. ; Chambers, Andrea S. ; Hitt, Sabrina K. ; Moreno, Francisco ; Manber, Rachel. / Acupuncture for depression : A randomized controlled trial. In: Journal of Clinical Psychiatry. 2006 ; Vol. 67, No. 11. pp. 1665-1673.
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