Acute cardiovascular effects of dimethyl sulfoxide

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Studies in extradural brain compression in rhesus monkeys, respiratory anoxia in rats, and spinal cord trauma in dogs suggest that DMSO=Dimethylsulfoxide may be more protective than steroids or barbiturates without altering neurological or cardiovascular function. While adverse cardiovascular effects of barbiturates have required corrective inotropic support in some clinical trials. DMSO cardiovascular effects are unclear. In vitro studies on mammalian myocardium have shown DMSO-induced depression of conduction and automaticity, but in vivo data on DMSO cardiovascular effects are lacking. In this study, the authors measured acute cardiovascular changes in barbiturate-anesthetized, normovolemic dogs receiving i.v. DMSO in doses of 2 g/kg, which were reported to have protective effects in cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
JournalAnnals of the New York Academy of Sciences
VolumeVol. 411
StatePublished - 1983

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Dimethyl Sulfoxide
Barbiturates
Dogs
Brain Ischemia
Macaca mulatta
Spinal Cord Injuries
Rats
Brain
Myocardium
Steroids
Clinical Trials
Dog

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Acute cardiovascular effects of dimethyl sulfoxide. / Hameroff, Stuart R; Otto, Charles W; Kanel, J.

In: Annals of the New York Academy of Sciences, Vol. Vol. 411, 1983, p. 94-99.

Research output: Contribution to journalArticle

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