Acute effects of haloperidol on cerebral cortex blood flow in normal and schizophrenic subjects

Ron G. Goldman, Gene E. Alexander, Zvi Zemishlany, Sukdeb Mukherjee, Harold Sackeim, Isak Prohovnik

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

To evaluate the effects of neuroleptic medications on cerebral blood flow (CBF), cortical perfusion was quantified by the 133xenon technique in 8 unmedicated schizophrenics and 9 healthy controls before, and 1 and 3 hours after, administration of haloperidol (5 mg per os). At 3 hours, the normal subjects, but not schizophrenic patients, showed a significant increase in global mean perfusion (17 ± 13%). Changes in CBF were not associated with plasma haloperidol levels or the presence of extrapyramidal side effects, and remained significant after controlling for pCO2. The lack of change in CBF in schizophrenic patients following acute haloperidol administration may be due to prior neuroleptic exposure, absence of anxiety, or other nonspecific factors, or may reflect a more fundamental feature of underlying pathophysiology in schizophrenia.

Original languageEnglish (US)
Pages (from-to)604-608
Number of pages5
JournalBiological Psychiatry
Volume40
Issue number7
DOIs
StatePublished - Oct 1 1996
Externally publishedYes

Keywords

  • brain imaging
  • cerebral blood flow
  • haloperidol neuroleptics
  • rCBF
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry

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