Acute graft-versus-host disease of the lung after liver transplantation

Kenneth S Knox, Mehrdad Behnia, Lisa R. Smith, Gail H. Vance, Michael Busk, Oscar W. Cummings, Paul Y. Kwo, David S. Wilkes

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12 Scopus citations

Abstract

We describe the first case of a man who developed acute graft-versus-host disease (GVHD), isolated to the lung, after an orthotopic liver transplant from a female donor. Our patient experienced dyspnea, worsening hypoxemia, and a progressive obstructive ventilatory defect 12 days after liver transplantation. Open-lung biopsy revealed grade 2 lymphocytic bronchiolitis, the pathologic and immunologic correlate of acute pulmonary GVHD. Fluorescent in situ hybridization confirmed donor cells at sites of peribronchiolar inflammation. High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipient.

Original languageEnglish (US)
Pages (from-to)968-971
Number of pages4
JournalLiver Transplantation
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 1 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Knox, K. S., Behnia, M., Smith, L. R., Vance, G. H., Busk, M., Cummings, O. W., ... Wilkes, D. S. (2002). Acute graft-versus-host disease of the lung after liver transplantation. Liver Transplantation, 8(10), 968-971. https://doi.org/10.1053/jlts.2002.35552