Acute leukemia in idiopathic sideroblastic anemia: Response to combination chemotherapy

K. K. Hussein, Z. Salem, S. S. Bottomley, Robert B Livingston

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Three patients with idiopathic sideroblastic anemia of variable duration developed acute leukemia. In two the leukemia was morphologically and histochemically myeloblastic, in one lymphoblastic. With combination chemotherapy remission was achieved in all three. The remission inductions were complicated by long periods of bone marrow suppression and the duration of remissions was brief (3, 2 and 3 months). Survival after diagnosis was 13, 10 and 9 mo, respectively. The ring sideroblast abnormality persisted during the leukemic and remission phases and transfusion requirements remained unaltered in the two patients with transfusion dependent anemia throughout their courses.

Original languageEnglish (US)
Pages (from-to)652-656
Number of pages5
JournalBlood
Volume59
Issue number3
StatePublished - 1982
Externally publishedYes

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Sideroblastic Anemia
Chemotherapy
Combination Drug Therapy
Bone
Leukemia
Remission Induction
Anemia
Bone Marrow
Survival

ASJC Scopus subject areas

  • Hematology

Cite this

Acute leukemia in idiopathic sideroblastic anemia : Response to combination chemotherapy. / Hussein, K. K.; Salem, Z.; Bottomley, S. S.; Livingston, Robert B.

In: Blood, Vol. 59, No. 3, 1982, p. 652-656.

Research output: Contribution to journalArticle

Hussein, KK, Salem, Z, Bottomley, SS & Livingston, RB 1982, 'Acute leukemia in idiopathic sideroblastic anemia: Response to combination chemotherapy', Blood, vol. 59, no. 3, pp. 652-656.
Hussein, K. K. ; Salem, Z. ; Bottomley, S. S. ; Livingston, Robert B. / Acute leukemia in idiopathic sideroblastic anemia : Response to combination chemotherapy. In: Blood. 1982 ; Vol. 59, No. 3. pp. 652-656.
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