Acute leukemia in idiopathic sideroblastic anemia: Response to combination chemotherapy

K. K. Hussein, Z. Salem, S. S. Bottomley, R. B. Livingston

Research output: Contribution to journalArticle

23 Scopus citations


Three patients with idiopathic sideroblastic anemia of variable duration developed acute leukemia. In two the leukemia was morphologically and histochemically myeloblastic, in one lymphoblastic. With combination chemotherapy remission was achieved in all three. The remission inductions were complicated by long periods of bone marrow suppression and the duration of remissions was brief (3, 2 and 3 months). Survival after diagnosis was 13, 10 and 9 mo, respectively. The ring sideroblast abnormality persisted during the leukemic and remission phases and transfusion requirements remained unaltered in the two patients with transfusion dependent anemia throughout their courses.

Original languageEnglish (US)
Pages (from-to)652-656
Number of pages5
Issue number3
StatePublished - Jan 1 1982


ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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