Adaptations in titin's spring elements in normal and cardiomyopathic hearts

Henk Granzier, Dietmar Labeit, Yiming Wu, Christian Witt, Kaori Watanabe, Sunshine Lahmers, Michael Gotthardt, Siegfried Labeit

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The giant elastic protein titin contains an extensible segment that underlies the majority of physiological passive muscle stiffness. The extensible segment comprises mechanically distinct and serially-linked spring elements: the tandem Ig segments, the PEVK and the cardiac-specific N2B unique sequence. Under physiological conditions the tandem Ig segments are likely to largely consist of folded Ig domains whereas the N2B unique sequence and PEVK are largely unfolded and behave as wormlike chains with different persistence lengths. The mechanical characteristics of titin's extensible region may be tuned to match changing mechanical demands placed on muscle, using mechanisms that operate at different time scales and that include post-transcriptional and post-translational processes.

Original languageEnglish (US)
Pages (from-to)517-531
Number of pages15
JournalAdvances in experimental medicine and biology
Volume538
StatePublished - 2004

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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