Adenoma characteristics as risk factors for recurrence of advanced adenomas

María Elena Martínez, Richard Sampliner, James R. Marshall, Achyut K Bhattacharyya, Mary E. Reid, David S Alberts

Research output: Contribution to journalArticle

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Abstract

Background & Aims: The link between adenoma characteristics at baseline colonoscopy and adenoma recurrence is poorly understood. We assessed whether the number, size, location, or histology of resected adenomas was related to the probability of recurrence of advanced lesions. Methods: Analyses were based on 1287 men and women in the wheat bran fiber (WBF) study, a randomized, double-blind trial of WBF as a means of decreasing the probability of adenoma recurrence over a period of 3 years. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (Cls). Results: Recurrence of advanced adenomas (>1 cm or tubulovillous/villous histology) was higher among individuals with adenomas >1 cm compared with those with adenomas <0.5 cm (OR, 2.69; 95% Cl, 1.34-5.42) and among those with proximal than those with distal adenomas (OR, 1.65; 95% Cl, 1.02-2.67). No association was observed for adenoma number or histology. A shift in location from the distal colon and rectum at baseline (54.6%) to more proximal recurrent adenomas (45.2%), including advanced lesions (42.8%), was observed. Conclusions: Large or proximally located adenomas are important indicators of recurrence of advanced lesions. Because most recurrences were detected in the proximal colon, careful surveillance of this area is warranted.

Original languageEnglish (US)
Pages (from-to)1077-1083
Number of pages7
JournalGastroenterology
Volume120
Issue number5
StatePublished - 2001

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Adenoma
Recurrence
Histology
Odds Ratio
Dietary Fiber
Colon
Colonoscopy
Rectum
Logistic Models
Confidence Intervals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Martínez, M. E., Sampliner, R., Marshall, J. R., Bhattacharyya, A. K., Reid, M. E., & Alberts, D. S. (2001). Adenoma characteristics as risk factors for recurrence of advanced adenomas. Gastroenterology, 120(5), 1077-1083.

Adenoma characteristics as risk factors for recurrence of advanced adenomas. / Martínez, María Elena; Sampliner, Richard; Marshall, James R.; Bhattacharyya, Achyut K; Reid, Mary E.; Alberts, David S.

In: Gastroenterology, Vol. 120, No. 5, 2001, p. 1077-1083.

Research output: Contribution to journalArticle

Martínez, ME, Sampliner, R, Marshall, JR, Bhattacharyya, AK, Reid, ME & Alberts, DS 2001, 'Adenoma characteristics as risk factors for recurrence of advanced adenomas', Gastroenterology, vol. 120, no. 5, pp. 1077-1083.
Martínez, María Elena ; Sampliner, Richard ; Marshall, James R. ; Bhattacharyya, Achyut K ; Reid, Mary E. ; Alberts, David S. / Adenoma characteristics as risk factors for recurrence of advanced adenomas. In: Gastroenterology. 2001 ; Vol. 120, No. 5. pp. 1077-1083.
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