Abstract
Background: Colorectal adenomas are the usual precursors to carcinoma in sporadic and hereditary colorectal cancers (CRC). Methods: A total of 220 CRC patients (stages 0, I, and II) were randomized prospectively in a double-blind pilot study of calcium chemoprevention by using recurrent colorectal adenomas as a surrogate end point. This trial is still in progress, and we report the preliminary findings on adenoma recurrence rates. Results: Synchronous adenomas were present in 60% of patients, and cancer confined in a polyp was present in 23% of patients. The overall cumulative adenoma recurrence rate was 31% (19% in the first year, 29% for 2 years, and 35% for 3 years). The recurrence rates were greater for patients with synchronous adenomas: 38% at 3 years (P = .01). Lower stage was associated with higher adenoma recurrence rates (P = .04). Factors including age, sex, site of primary cancer, and whether the cancer was confined to a polyp were not significantly associated with differences in adenoma recurrence rates. Conclusions: The substantial adenoma recurrence rate in patients resected of CRC justifies colonoscopic surveillance on a periodic basis. Patients with higher rates of adenoma recurrences, such as CRC with synchronous adenomas, are ideal subjects for chemoprevention trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 870-875 |
| Number of pages | 6 |
| Journal | Annals of Surgical Oncology |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2003 |
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Keywords
- Adenoma
- Adenoma recurrence rate
- Colorectal cancer
- Synchronous adenoma
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Adenoma recurrences after resection of colorectal carcinoma : Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study. / Chu, David Z J; Chansky, Kari; Alberts, David S; Meyskens, Frank L.; Fenoglio-Preiser, Cecilia M.; Rivkin, Saul E.; Mills, Glenn M.; Giguere, Jeffrey K.; Goodman, Gary E.; Abbruzzese, James L.; Lippman, Scott M.
In: Annals of Surgical Oncology, Vol. 10, No. 8, 2003, p. 870-875.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adenoma recurrences after resection of colorectal carcinoma
T2 - Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study
AU - Chu, David Z J
AU - Chansky, Kari
AU - Alberts, David S
AU - Meyskens, Frank L.
AU - Fenoglio-Preiser, Cecilia M.
AU - Rivkin, Saul E.
AU - Mills, Glenn M.
AU - Giguere, Jeffrey K.
AU - Goodman, Gary E.
AU - Abbruzzese, James L.
AU - Lippman, Scott M.
PY - 2003
Y1 - 2003
N2 - Background: Colorectal adenomas are the usual precursors to carcinoma in sporadic and hereditary colorectal cancers (CRC). Methods: A total of 220 CRC patients (stages 0, I, and II) were randomized prospectively in a double-blind pilot study of calcium chemoprevention by using recurrent colorectal adenomas as a surrogate end point. This trial is still in progress, and we report the preliminary findings on adenoma recurrence rates. Results: Synchronous adenomas were present in 60% of patients, and cancer confined in a polyp was present in 23% of patients. The overall cumulative adenoma recurrence rate was 31% (19% in the first year, 29% for 2 years, and 35% for 3 years). The recurrence rates were greater for patients with synchronous adenomas: 38% at 3 years (P = .01). Lower stage was associated with higher adenoma recurrence rates (P = .04). Factors including age, sex, site of primary cancer, and whether the cancer was confined to a polyp were not significantly associated with differences in adenoma recurrence rates. Conclusions: The substantial adenoma recurrence rate in patients resected of CRC justifies colonoscopic surveillance on a periodic basis. Patients with higher rates of adenoma recurrences, such as CRC with synchronous adenomas, are ideal subjects for chemoprevention trials.
AB - Background: Colorectal adenomas are the usual precursors to carcinoma in sporadic and hereditary colorectal cancers (CRC). Methods: A total of 220 CRC patients (stages 0, I, and II) were randomized prospectively in a double-blind pilot study of calcium chemoprevention by using recurrent colorectal adenomas as a surrogate end point. This trial is still in progress, and we report the preliminary findings on adenoma recurrence rates. Results: Synchronous adenomas were present in 60% of patients, and cancer confined in a polyp was present in 23% of patients. The overall cumulative adenoma recurrence rate was 31% (19% in the first year, 29% for 2 years, and 35% for 3 years). The recurrence rates were greater for patients with synchronous adenomas: 38% at 3 years (P = .01). Lower stage was associated with higher adenoma recurrence rates (P = .04). Factors including age, sex, site of primary cancer, and whether the cancer was confined to a polyp were not significantly associated with differences in adenoma recurrence rates. Conclusions: The substantial adenoma recurrence rate in patients resected of CRC justifies colonoscopic surveillance on a periodic basis. Patients with higher rates of adenoma recurrences, such as CRC with synchronous adenomas, are ideal subjects for chemoprevention trials.
KW - Adenoma
KW - Adenoma recurrence rate
KW - Colorectal cancer
KW - Synchronous adenoma
UR - http://www.scopus.com/inward/record.url?scp=1542649566&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542649566&partnerID=8YFLogxK
U2 - 10.1245/ASO.2003.03.037
DO - 10.1245/ASO.2003.03.037
M3 - Article
VL - 10
SP - 870
EP - 875
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 8
ER -