Adenoma recurrences after resection of colorectal carcinoma: Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study

David Z.J. Chu, Kari Chansky, David S. Alberts, Frank L. Meyskens, Cecilia M. Fenoglio-Preiser, Saul E. Rivkin, Glenn M. Mills, Jeffrey K. Giguere, Gary E. Goodman, James L. Abbruzzese, Scott M. Lippman

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Colorectal adenomas are the usual precursors to carcinoma in sporadic and hereditary colorectal cancers (CRC). Methods: A total of 220 CRC patients (stages 0, I, and II) were randomized prospectively in a double-blind pilot study of calcium chemoprevention by using recurrent colorectal adenomas as a surrogate end point. This trial is still in progress, and we report the preliminary findings on adenoma recurrence rates. Results: Synchronous adenomas were present in 60% of patients, and cancer confined in a polyp was present in 23% of patients. The overall cumulative adenoma recurrence rate was 31% (19% in the first year, 29% for 2 years, and 35% for 3 years). The recurrence rates were greater for patients with synchronous adenomas: 38% at 3 years (P = .01). Lower stage was associated with higher adenoma recurrence rates (P = .04). Factors including age, sex, site of primary cancer, and whether the cancer was confined to a polyp were not significantly associated with differences in adenoma recurrence rates. Conclusions: The substantial adenoma recurrence rate in patients resected of CRC justifies colonoscopic surveillance on a periodic basis. Patients with higher rates of adenoma recurrences, such as CRC with synchronous adenomas, are ideal subjects for chemoprevention trials.

Original languageEnglish (US)
Pages (from-to)870-875
Number of pages6
JournalAnnals of Surgical Oncology
Volume10
Issue number8
DOIs
StatePublished - Dec 1 2003

Keywords

  • Adenoma
  • Adenoma recurrence rate
  • Colorectal cancer
  • Synchronous adenoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Chu, D. Z. J., Chansky, K., Alberts, D. S., Meyskens, F. L., Fenoglio-Preiser, C. M., Rivkin, S. E., Mills, G. M., Giguere, J. K., Goodman, G. E., Abbruzzese, J. L., & Lippman, S. M. (2003). Adenoma recurrences after resection of colorectal carcinoma: Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study. Annals of Surgical Oncology, 10(8), 870-875. https://doi.org/10.1245/ASO.2003.03.037