Adenoma recurrences after resection of colorectal carcinoma

Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study

David Z J Chu, Kari Chansky, David S Alberts, Frank L. Meyskens, Cecilia M. Fenoglio-Preiser, Saul E. Rivkin, Glenn M. Mills, Jeffrey K. Giguere, Gary E. Goodman, James L. Abbruzzese, Scott M. Lippman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Colorectal adenomas are the usual precursors to carcinoma in sporadic and hereditary colorectal cancers (CRC). Methods: A total of 220 CRC patients (stages 0, I, and II) were randomized prospectively in a double-blind pilot study of calcium chemoprevention by using recurrent colorectal adenomas as a surrogate end point. This trial is still in progress, and we report the preliminary findings on adenoma recurrence rates. Results: Synchronous adenomas were present in 60% of patients, and cancer confined in a polyp was present in 23% of patients. The overall cumulative adenoma recurrence rate was 31% (19% in the first year, 29% for 2 years, and 35% for 3 years). The recurrence rates were greater for patients with synchronous adenomas: 38% at 3 years (P = .01). Lower stage was associated with higher adenoma recurrence rates (P = .04). Factors including age, sex, site of primary cancer, and whether the cancer was confined to a polyp were not significantly associated with differences in adenoma recurrence rates. Conclusions: The substantial adenoma recurrence rate in patients resected of CRC justifies colonoscopic surveillance on a periodic basis. Patients with higher rates of adenoma recurrences, such as CRC with synchronous adenomas, are ideal subjects for chemoprevention trials.

Original languageEnglish (US)
Pages (from-to)870-875
Number of pages6
JournalAnnals of Surgical Oncology
Volume10
Issue number8
DOIs
StatePublished - 2003

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Chemoprevention
Adenoma
Colorectal Neoplasms
Calcium
Recurrence
Polyps
Neoplasms
Age Factors
Double-Blind Method
Biomarkers
Carcinoma

Keywords

  • Adenoma
  • Adenoma recurrence rate
  • Colorectal cancer
  • Synchronous adenoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Adenoma recurrences after resection of colorectal carcinoma : Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study. / Chu, David Z J; Chansky, Kari; Alberts, David S; Meyskens, Frank L.; Fenoglio-Preiser, Cecilia M.; Rivkin, Saul E.; Mills, Glenn M.; Giguere, Jeffrey K.; Goodman, Gary E.; Abbruzzese, James L.; Lippman, Scott M.

In: Annals of Surgical Oncology, Vol. 10, No. 8, 2003, p. 870-875.

Research output: Contribution to journalArticle

Chu, DZJ, Chansky, K, Alberts, DS, Meyskens, FL, Fenoglio-Preiser, CM, Rivkin, SE, Mills, GM, Giguere, JK, Goodman, GE, Abbruzzese, JL & Lippman, SM 2003, 'Adenoma recurrences after resection of colorectal carcinoma: Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study', Annals of Surgical Oncology, vol. 10, no. 8, pp. 870-875. https://doi.org/10.1245/ASO.2003.03.037
Chu, David Z J ; Chansky, Kari ; Alberts, David S ; Meyskens, Frank L. ; Fenoglio-Preiser, Cecilia M. ; Rivkin, Saul E. ; Mills, Glenn M. ; Giguere, Jeffrey K. ; Goodman, Gary E. ; Abbruzzese, James L. ; Lippman, Scott M. / Adenoma recurrences after resection of colorectal carcinoma : Results from the Southwest Oncology Group 9041 calcium chemoprevention pilot study. In: Annals of Surgical Oncology. 2003 ; Vol. 10, No. 8. pp. 870-875.
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AU - Meyskens, Frank L.

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