Adherence of Candida albicans to components of the subendothelial extracellular matrix

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Candida albicans yeasts adhered avidly to extracellular matrix (ECM) proteins, type IV collagen, laminin, and fibronectin immobilized on plastic. Type IV collagen showed an increase of adherence of 400% above control values; laminin, 300%; and fibronectin, 150%. In addition, all three (in quantities of 0.02-200 μg/well of a culture tray) bound yeasts in a dose-response fashion. Adherence was inhibited when the proteins were preincubated with specific antibody, except with type IV collagen. Soluble laminin or fibronectin inhibited yeast adherence to the same proteins by 36 and 94%, respectively. Soluble fibronectin bound to the yeast surface and in so doing inhibited subsequent yeast adherence to fibronectin by 66%. By comparison, Candida albicans yeasts adhered in smaller numbers to glycosaminoglycans (GAGs). Keratan sulfate, hyaluronic acid, chondroitin sulfate, Type B, and heparin actually decreased yeast adherence compared to control from 10% to 25%.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalFEMS Microbiology Letters
Volume68
Issue number3
DOIs
StatePublished - Mar 15 1990
Externally publishedYes

Fingerprint

Candida albicans
Extracellular Matrix
Yeasts
Fibronectins
Collagen Type IV
Laminin
Keratan Sulfate
Dermatan Sulfate
Extracellular Matrix Proteins
Hyaluronic Acid
Glycosaminoglycans
Plastics
Heparin
Proteins
Antibodies

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Adherence of Candida albicans to components of the subendothelial extracellular matrix. / Klotz, Stephen A.

In: FEMS Microbiology Letters, Vol. 68, No. 3, 15.03.1990, p. 249-253.

Research output: Contribution to journalArticle

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