Adhesion molecule increases in sleep apnea: Beneficial effect of positive airway pressure and moderation by obesity

V. M. Pak, B. T. Keenan, N. Jackson, M. A. Grandner, G. Maislin, K. Teff, R. J. Schwab, E. S. Arnardottir, S. Júlíusson, B. Benediktsdottir, T. Gislason, A. I. Pack

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background:Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear.Objective:Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes.Subjects/Methods:The mean body mass index (BMI) was 32.4±5.1 kg m - 2; subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79% were male. There were 177 full PAP users (≥4 h per night and ≥20 of last 28 nights), 44 partial (<4 h per night or <20 nights) and 88 nonusers.Results:ICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, nonusers had increased ICAM-1 compared with decreased levels in full users. All groups had increased VCAM-1, but nonusers had a significantly larger increase than full users.Conclusions:Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)472-479
Number of pages8
JournalInternational Journal of Obesity
Volume39
Issue number3
DOIs
StatePublished - Mar 12 2015
Externally publishedYes

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Sleep Apnea Syndromes
Obstructive Sleep Apnea
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1
Obesity
Pressure
Cardiovascular Diseases
Apnea
Body Mass Index

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Adhesion molecule increases in sleep apnea : Beneficial effect of positive airway pressure and moderation by obesity. / Pak, V. M.; Keenan, B. T.; Jackson, N.; Grandner, M. A.; Maislin, G.; Teff, K.; Schwab, R. J.; Arnardottir, E. S.; Júlíusson, S.; Benediktsdottir, B.; Gislason, T.; Pack, A. I.

In: International Journal of Obesity, Vol. 39, No. 3, 12.03.2015, p. 472-479.

Research output: Contribution to journalArticle

Pak, VM, Keenan, BT, Jackson, N, Grandner, MA, Maislin, G, Teff, K, Schwab, RJ, Arnardottir, ES, Júlíusson, S, Benediktsdottir, B, Gislason, T & Pack, AI 2015, 'Adhesion molecule increases in sleep apnea: Beneficial effect of positive airway pressure and moderation by obesity', International Journal of Obesity, vol. 39, no. 3, pp. 472-479. https://doi.org/10.1038/ijo.2014.123
Pak, V. M. ; Keenan, B. T. ; Jackson, N. ; Grandner, M. A. ; Maislin, G. ; Teff, K. ; Schwab, R. J. ; Arnardottir, E. S. ; Júlíusson, S. ; Benediktsdottir, B. ; Gislason, T. ; Pack, A. I. / Adhesion molecule increases in sleep apnea : Beneficial effect of positive airway pressure and moderation by obesity. In: International Journal of Obesity. 2015 ; Vol. 39, No. 3. pp. 472-479.
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abstract = "Background:Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear.Objective:Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes.Subjects/Methods:The mean body mass index (BMI) was 32.4±5.1 kg m - 2; subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79{\%} were male. There were 177 full PAP users (≥4 h per night and ≥20 of last 28 nights), 44 partial (<4 h per night or <20 nights) and 88 nonusers.Results:ICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, nonusers had increased ICAM-1 compared with decreased levels in full users. All groups had increased VCAM-1, but nonusers had a significantly larger increase than full users.Conclusions:Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease.",
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T2 - Beneficial effect of positive airway pressure and moderation by obesity

AU - Pak, V. M.

AU - Keenan, B. T.

AU - Jackson, N.

AU - Grandner, M. A.

AU - Maislin, G.

AU - Teff, K.

AU - Schwab, R. J.

AU - Arnardottir, E. S.

AU - Júlíusson, S.

AU - Benediktsdottir, B.

AU - Gislason, T.

AU - Pack, A. I.

PY - 2015/3/12

Y1 - 2015/3/12

N2 - Background:Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear.Objective:Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes.Subjects/Methods:The mean body mass index (BMI) was 32.4±5.1 kg m - 2; subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79% were male. There were 177 full PAP users (≥4 h per night and ≥20 of last 28 nights), 44 partial (<4 h per night or <20 nights) and 88 nonusers.Results:ICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, nonusers had increased ICAM-1 compared with decreased levels in full users. All groups had increased VCAM-1, but nonusers had a significantly larger increase than full users.Conclusions:Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease.

AB - Background:Elevated levels of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) may contribute to cardiovascular disease and are associated with obstructive sleep apnea (OSA) and obesity. The relationship between OSA and obesity in determining ICAM-1 and VCAM-1 levels, and the effect of treatment, is unclear.Objective:Our aim was to study whether positive airway pressure (PAP) usage resulted in changes in ICAM-1 and VCAM-1 after 2 years within 309 OSA patients from the Icelandic Sleep Apnea Cohort, and determine how obesity affected such changes.Subjects/Methods:The mean body mass index (BMI) was 32.4±5.1 kg m - 2; subjects had moderate-to-severe OSA (apnea-hypopnea index=45.0±20.2) and 79% were male. There were 177 full PAP users (≥4 h per night and ≥20 of last 28 nights), 44 partial (<4 h per night or <20 nights) and 88 nonusers.Results:ICAM-1 (P<0.001) and VCAM-1 (P=0.012) change was significantly different among the PAP groups. The largest ICAM-1 differences were among the most obese subjects (P<0.001). At follow-up, nonusers had increased ICAM-1 compared with decreased levels in full users. All groups had increased VCAM-1, but nonusers had a significantly larger increase than full users.Conclusions:Within moderate-to-severe OSA patients, PAP usage prevents increases in adhesion molecules observed in nonusers after 2 years. For ICAM-1, the largest effect is in the most obese subjects. As OSA and obesity commonly coexist, the usage of PAP to limit increases in adhesion molecules may decrease the rate of progression of OSA-related cardiovascular disease.

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