Adipose tissue fatty acid metabolism during pregnancy in swine.

J. P. McNamara, M. H. Dehoff, Robert J Collier, F. W. Bazer

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

In vitro adipose tissue fatty acid pool size (POOL), fatty acid release (FAR) and esterification (EST) were measured in peritoneal (PFP) and subcutaneous mammary (MFP) fat pads of swine at d 15, 30, 45, 60, 75, 90, 105 and 112 of pregnancy. Plasma free fatty acids (FFA) and triglycerides (TG) were not altered by stage of pregnancy. Basal EST in PFP was generally constant across pregnancy with a peak at d 75. Basal EST in MFP was elevated at d 30, 75 and 112. Esterification in response to norepinephrine stimulus (NE) was lower than basal rates in both fat depots. Basal FAR was constant throughout pregnancy in PFP, but elevated at d 75 and 90 in MFP. Fatty acid release in response to NE was biphasic with peaks at d 30 and in late pregnancy (in MFP, micromolar FAR in response to NE was 69.3% greater on d 75 to 112 than on d 45 to 60). Basal POOL was constant throughout pregnancy in both depots and lower than NE-stimulated POOL. All responses to NE were greater in MFP than in PFP, indicating that adipose tissue surrounding the developing mammary gland had higher metabolic activity and a greater response to NE than peritoneal adipose. Changes in fatty acid metabolism during pregnancy in swine are temporally related to published values for plasma steroids, fetal growth and mammary development. Metabolic adaptations in adipose and mannary epithelial tissue occur in synchrony with changing plasma estrogen concentrations, redirecting energy flow from maternal adipose tissue toward developing mammary and fetal tissue.

Original languageEnglish (US)
Pages (from-to)410-415
Number of pages6
JournalJournal of Animal Science
Volume61
Issue number2
StatePublished - Aug 1985
Externally publishedYes

Fingerprint

fatty acid metabolism
adipose tissue
norepinephrine
Adipose Tissue
Swine
Fatty Acids
pregnancy
Norepinephrine
Esterification
Pregnancy
esterification
swine
fatty acids
Breast
breasts
mammary development
energy flow
fetal development
Human Mammary Glands
lipids

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

McNamara, J. P., Dehoff, M. H., Collier, R. J., & Bazer, F. W. (1985). Adipose tissue fatty acid metabolism during pregnancy in swine. Journal of Animal Science, 61(2), 410-415.

Adipose tissue fatty acid metabolism during pregnancy in swine. / McNamara, J. P.; Dehoff, M. H.; Collier, Robert J; Bazer, F. W.

In: Journal of Animal Science, Vol. 61, No. 2, 08.1985, p. 410-415.

Research output: Contribution to journalArticle

McNamara, JP, Dehoff, MH, Collier, RJ & Bazer, FW 1985, 'Adipose tissue fatty acid metabolism during pregnancy in swine.', Journal of Animal Science, vol. 61, no. 2, pp. 410-415.
McNamara, J. P. ; Dehoff, M. H. ; Collier, Robert J ; Bazer, F. W. / Adipose tissue fatty acid metabolism during pregnancy in swine. In: Journal of Animal Science. 1985 ; Vol. 61, No. 2. pp. 410-415.
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