Admixture mapping links RACGAP1 regulation to prostate cancer in African Americans

Bradford D. Wilson, Luisel J. Ricks-Santi, Tshela E. Mason, Muneer Abbas, Rick A. Kittles, Georgia M. Dunston, Yasmine M. Kanaan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background/Aim: Prostate cancer is the most common malignancy in US males. African American men have higher incidence and mortality rates than European Americans. Five single nucleotide polymorphisms are associated with PCa. We hypothesized haplotypes inferred from these SNPs are also associated with PCa. Patients and Methods: We genotyped SNPs in a case-control admixture mapping study. SNP haplotypes inferred for 157 PCa cases and 150 controls were used in the regression analysis. Results: We found an association between “GTCCC”, “ATTCT”, and “ACCCC” haplotypes and PCa after ancestry adjustment (OR=3.62, 95%CI=1.42-9.21, p=0.0070; OR=7.89, 95%CI=2.36-26.31, p=0.0008; OR=4.34, 95%CI=1.75-10.78, p=0.0016). The rs615382 variant disrupts the recombination signal binding protein with immunoglobulin kappa J binding site in Rac GTPase activating protein 1 (RACGAP1). Conclusion: Disruption of notch 1 mediated-repression of RACGAP1 may contribute to PCa in African Americans.

Original languageEnglish (US)
Pages (from-to)185-191
Number of pages7
JournalCancer Genomics and Proteomics
Volume15
Issue number3
DOIs
StatePublished - May 1 2018

Keywords

  • African Americans
  • Prostate cancer
  • RACGAP1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

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  • Cite this

    Wilson, B. D., Ricks-Santi, L. J., Mason, T. E., Abbas, M., Kittles, R. A., Dunston, G. M., & Kanaan, Y. M. (2018). Admixture mapping links RACGAP1 regulation to prostate cancer in African Americans. Cancer Genomics and Proteomics, 15(3), 185-191. https://doi.org/10.21873/cgp.20076