ADP receptor-blocker thienopyridines: Chemical structures, mode of action and clinical use. A review

Mehrnoosh Hashemzadeh, Sarah Goldsberry, Matthew Furukawa, Ali Khoynezhad, Mohammad Reza Movahed

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

One of the major classes of adenosine diphosphate (ADP) receptor antagonists are thienopyridines. Thienopyridines compose a subcategory of antiplatelet medications, known as ADP receptor inhibitors, used commonly for the treatment of atherosclerotic cardiovascular disease. Thienopyridines, including ticlopidine, clopidogrel and prasugrel, are prodrugs administered orally that are further metabolized by hepatocytes to create active metabolites that irreversibly bind ADP receptors located on the platelet membrane. Thus, these selected drugs have an inhibitory effect for the duration of the platelet's lifespan of 7-10 days. The goal of this manuscript is to review the currently available ADP receptor blockers with emphasis on chemical structure, mode of action and clinical use.

Original languageEnglish (US)
Pages (from-to)406-412
Number of pages7
JournalJournal of Invasive Cardiology
Volume21
Issue number8
StatePublished - Aug 1 2009

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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