Adrenal medulla denervation prevents stress-induced epinephrine plasma elevation and cardiac hypertrophy

J. R. Womble, D. F. Larson, J. G. Copeland, B. R. Brown, Mari K. Haddox, Diane Haddock Russell

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Circulating catecholamines have been proposed as trophic agents for the heart. Denervation of the adrenal medullae, the major source of plasma epinephrine, totally blocked left ventricular hypertrophy after aortic coarctation in the dog. The level of epinephrine after adrenal medullary cholinergic denervation dropped to a mean of 10 pg/ml within 48 hours compared to 317 pg/ml in coarcted dogs with intact adrenal innervation, and 116 pg/ml in sham-coarcted controls. Decreased epinephrine levels were concomitant with a decrease in the heart weight to body weight ratios. These data implicate epinephrine as the specific hormone regulating cardiac hypertrophy.

Original languageEnglish (US)
Pages (from-to)2417-2420
Number of pages4
JournalLife Sciences
Volume27
Issue number24
DOIs
StatePublished - Dec 15 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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