Adrenocorticotropic hormone may be transported directly from the pituitary to the brain

R. Bergland, H. Blume, Allan J Hamilton, P. Monica, R. Paterson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Experiments were designed to test the hypothesis that pituitary hormones may be delivered directly to the brain. Concentrations of adrenocorticotropic hormone (ACTH) in the plasma were determined in blood samples obtained simultaneously from the carotid artery, the sagittal sinus, and the jugular vein of three awake sheep. Seizures were induced electrically to stimulate ACTH secretion, and at precise intervals thereafter several simultaneous comparisons were made in each animal. In many of the post-seizure comparisons, the ACTH plasma concentrations within the sagittal sinus exceeded those within the carotid artery as well as those within the jugular vein, indicating that this hormone was released from the pituitary and carried directly through capillary beds of brain to the venous blood within the sagittal sinus. The experiment was repeated in one hypophysectomized sheep and, in this animal, ACTH concentration in the plasma was reduced, but that in the sagittal sinus still was elevated after the seizure, an indication that some ACTH (or ACTH-like material) was released from the brain itself.

Original languageEnglish (US)
Pages (from-to)541-543
Number of pages3
JournalScience
Volume210
Issue number4469
StatePublished - Jan 1 1980
Externally publishedYes

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Adrenocorticotropic Hormone
Brain
Seizures
Jugular Veins
Carotid Arteries
Sheep
Pituitary Hormones
Hormones

ASJC Scopus subject areas

  • General

Cite this

Bergland, R., Blume, H., Hamilton, A. J., Monica, P., & Paterson, R. (1980). Adrenocorticotropic hormone may be transported directly from the pituitary to the brain. Science, 210(4469), 541-543.

Adrenocorticotropic hormone may be transported directly from the pituitary to the brain. / Bergland, R.; Blume, H.; Hamilton, Allan J; Monica, P.; Paterson, R.

In: Science, Vol. 210, No. 4469, 01.01.1980, p. 541-543.

Research output: Contribution to journalArticle

Bergland, R, Blume, H, Hamilton, AJ, Monica, P & Paterson, R 1980, 'Adrenocorticotropic hormone may be transported directly from the pituitary to the brain', Science, vol. 210, no. 4469, pp. 541-543.
Bergland R, Blume H, Hamilton AJ, Monica P, Paterson R. Adrenocorticotropic hormone may be transported directly from the pituitary to the brain. Science. 1980 Jan 1;210(4469):541-543.
Bergland, R. ; Blume, H. ; Hamilton, Allan J ; Monica, P. ; Paterson, R. / Adrenocorticotropic hormone may be transported directly from the pituitary to the brain. In: Science. 1980 ; Vol. 210, No. 4469. pp. 541-543.
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