Adrenomedullin levels in normal and preeclamptic pregnancy at term

Michele R. Lauria, Cynthia A. Standley, Yoram Sorokin, Frank D. Yelian, David B. Cotton

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Objective: To describe maternal plasma levels of adrenomedullin (AM), a hypotensive and natriuretic peptide, in normal and preeclamptic women at term. Study design: Maternal plasma AM levels were determined in 13 preeclamptic and 15 normotensive primigravidas by radioimmunoassay. Plasma samples were obtained with the patients in the lateral recumbent position before the administration of any medications. Results: Women with preeclampsia had significantly elevated AM levels when compared with normotensive controls (42.3 ± 10.5 pg/mL versus 16.9 ± 3.1 pg/mL, P < .011). Conclusion: In this pilot study, AM levels were significantly increased at term in preeclamptic women.

Original languageEnglish (US)
Pages (from-to)318-321
Number of pages4
JournalJournal of the Society for Gynecologic Investigation
Volume6
Issue number6
DOIs
StatePublished - Nov 1 1999

Keywords

  • Adrenomedullin
  • Preeclampsia
  • Vasoactive agents

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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