Advanced age dissociates dual functions of the perirhinal cortex

Sara N. Burke, Andrew P. Maurer, Saman Nematollahi, Ajay Uprety, Jenelle L. Wallace, Carol A. Barnes

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The perirhinal cortex (PRC) is proposed to both represent high-order sensory information and maintain those representations across delays. These cognitive processes are required for recognition memory, which declines during normal aging. Whether or not advanced age affects the ability of PRC principal cells to support these dual roles, however, is not known. The current experiment recorded PRC neurons as young and aged rats traversed a track.Whenobjects were placed on the track, a subset of the neurons became active at discrete locations adjacent to objects. Importantly, the aged rats had a lower proportion of neurons that were activated by objects. Once PRC activity patterns in the presence of objects were established, however, both age groups maintained these representations across delays up to 2 h. These data support the hypothesis that age-associated deficits in stimulus recognition arise from impairments in high-order stimulus representation rather than difficulty in sustaining stable activity patterns over time.

Original languageEnglish (US)
Pages (from-to)467-480
Number of pages14
JournalJournal of Neuroscience
Volume34
Issue number2
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Advanced age dissociates dual functions of the perirhinal cortex'. Together they form a unique fingerprint.

Cite this