Advanced infrared glasses for biochemical sensing

Pierre Lucas, Bruno Bureau

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

This chapter reviews the use of fiber evanescent wave spectroscopy (FEWS) for the characterization of biological materials. It focuses on the use of chalcogenide fibers and their application in biochemical sensing. The FEWS technique is a recent but promising analytical method for the study of biointerfaces. It makes use of infrared transparent fiber probes to guide the light source to the sample and collect the resulting signal onto a detector. This technique has recently gained much interest and has found applications in a wide range of fields, including biomedical sensing, cancer diagnosis, and in vivo monitoring of cells. It combines the advantages of Fourier transform infrared (FTIR) with the versatility of fiber sensing. This provides high selectivity of FTIR as well as the ability to probe biointerfaces in situ and in real time. Moreover, the design of appropriate sensing probes can lead to a notable increase in sensitivity and the hydrophobic nature of the glass surface promotes the signal of biomolecule versus water, making this technique a great candidate for biosensing in aqueous environments. The field of FTIR is in constant development and new improvements are regularly reported. In most cases these new advances can be directly applied to the FEWS technique and should further increase its sensitivity and detection limit in the future.

Original languageEnglish (US)
Title of host publicationBiointerface Characterization by Advanced IR Spectroscopy
PublisherElsevier
Pages217-243
Number of pages27
ISBN (Print)9780444535580
DOIs
StatePublished - Dec 1 2011

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ASJC Scopus subject areas

  • Chemical Engineering(all)

Cite this

Lucas, P., & Bureau, B. (2011). Advanced infrared glasses for biochemical sensing. In Biointerface Characterization by Advanced IR Spectroscopy (pp. 217-243). Elsevier. https://doi.org/10.1016/B978-0-444-53558-0.00008-4