Advanced parental age and the risk of autism spectrum disorder

Maureen S. Durkin, Matthew J. Maenner, Craig J. Newschaffer, Li Ching Lee, Christopher M Cunniff, Julie L. Daniels, Russell S. Kirby, Lewis Leavitt, Lisa Miller, Walter Zahorodny, Laura A. Schieve

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age ≥35 vs. 25-29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age ≥40 years vs. 25-29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20-34 years and fathers aged <40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology.

Original languageEnglish (US)
Pages (from-to)1268-1276
Number of pages9
JournalAmerican Journal of Epidemiology
Volume168
Issue number11
DOIs
StatePublished - Dec 2008

Fingerprint

Paternal Age
Autistic Disorder
Maternal Age
Parents
Odds Ratio
Parturition
Confidence Intervals
Mothers
Developmental Disabilities
Health Planning
Birth Order
Centers for Disease Control and Prevention (U.S.)
Fathers
Diagnostic and Statistical Manual of Mental Disorders
Public Health
Autism Spectrum Disorder
Education

Keywords

  • Autistic disorder
  • Birth order
  • Maternal age
  • Paternal age

ASJC Scopus subject areas

  • Epidemiology

Cite this

Durkin, M. S., Maenner, M. J., Newschaffer, C. J., Lee, L. C., Cunniff, C. M., Daniels, J. L., ... Schieve, L. A. (2008). Advanced parental age and the risk of autism spectrum disorder. American Journal of Epidemiology, 168(11), 1268-1276. https://doi.org/10.1093/aje/kwn250

Advanced parental age and the risk of autism spectrum disorder. / Durkin, Maureen S.; Maenner, Matthew J.; Newschaffer, Craig J.; Lee, Li Ching; Cunniff, Christopher M; Daniels, Julie L.; Kirby, Russell S.; Leavitt, Lewis; Miller, Lisa; Zahorodny, Walter; Schieve, Laura A.

In: American Journal of Epidemiology, Vol. 168, No. 11, 12.2008, p. 1268-1276.

Research output: Contribution to journalArticle

Durkin, MS, Maenner, MJ, Newschaffer, CJ, Lee, LC, Cunniff, CM, Daniels, JL, Kirby, RS, Leavitt, L, Miller, L, Zahorodny, W & Schieve, LA 2008, 'Advanced parental age and the risk of autism spectrum disorder', American Journal of Epidemiology, vol. 168, no. 11, pp. 1268-1276. https://doi.org/10.1093/aje/kwn250
Durkin MS, Maenner MJ, Newschaffer CJ, Lee LC, Cunniff CM, Daniels JL et al. Advanced parental age and the risk of autism spectrum disorder. American Journal of Epidemiology. 2008 Dec;168(11):1268-1276. https://doi.org/10.1093/aje/kwn250
Durkin, Maureen S. ; Maenner, Matthew J. ; Newschaffer, Craig J. ; Lee, Li Ching ; Cunniff, Christopher M ; Daniels, Julie L. ; Kirby, Russell S. ; Leavitt, Lewis ; Miller, Lisa ; Zahorodny, Walter ; Schieve, Laura A. / Advanced parental age and the risk of autism spectrum disorder. In: American Journal of Epidemiology. 2008 ; Vol. 168, No. 11. pp. 1268-1276.
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