Advances and challenges in biosensor-based diagnosis of infectious diseases

Mandy Ly Sin, Kathleen E. Mach, Pak Kin Wong, Joseph C. Liao

Research output: Contribution to journalReview article

149 Scopus citations

Abstract

Rapid diagnosis of infectious diseases and timely initiation of appropriate treatment are critical determinants that promote optimal clinical outcomes and general public health. Conventional in vitro diagnostics for infectious diseases are time-consuming and require centralized laboratories, experienced personnel and bulky equipment. Recent advances in biosensor technologies have potential to deliver point-of-care diagnostics that match or surpass conventional standards in regards to time, accuracy and cost. Broadly classified as either label-free or labeled, modern biosensors exploit micro- and nanofabrication technologies and diverse sensing strategies including optical, electrical and mechanical transducers. Despite clinical need, translation of biosensors from research laboratories to clinical applications has remained limited to a few notable examples, such as the glucose sensor. Challenges to be overcome include sample preparation, matrix effects and system integration. We review the advances of biosensors for infectious disease diagnostics and discuss the critical challenges that need to be overcome in order to implement integrated diagnostic biosensors in real world settings.

Original languageEnglish (US)
Pages (from-to)225-244
Number of pages20
JournalExpert Review of Molecular Diagnostics
Volume14
Issue number2
DOIs
StatePublished - Mar 1 2014

Keywords

  • biosensor
  • infectious diseases
  • matrix effects
  • microfluidics
  • sample preparation
  • system integration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

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