Advances in asthma, allergy mechanisms, and genetics in 2006

Fred D. Finkelman, Donata Vercelli

Research output: Contribution to journalReview article

49 Scopus citations

Abstract

This review discusses the main advances in animal models of allergic airway disease and genetics of asthma and allergy published in the Journal in 2006. This work highlighted and extended what has become the central dogma of allergic pathogenesis by highlighting the mechanisms involved in inducing a TH2 response and in determining how TH2 cytokines induce the allergic airway disease phenotype. By so doing, they have identified a considerable number of potential therapeutic targets. Genetic analyses, on the other hand, revealed novel, potentially important candidate genes, confirmed known ones, and refined our understanding of the putative role played by others, sometimes positively, sometimes negatively. These data reiterate allergic inflammation is a classic complex genetic disease-that is, a disorder in which multiple and distinct genetic determinants variously interact with one another and with relevant environmental exposures to result in clinical phenotypes that, although superficially similar, involve distinct genetic pathways and represent the outcome of distinct pathogenetic mechanisms.

Original languageEnglish (US)
Pages (from-to)544-550
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume120
Issue number3
DOIs
StatePublished - Sep 1 2007

Keywords

  • Allergy
  • association studies
  • asthma
  • genetics
  • linkage studies
  • mechanisms
  • mouse models
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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