Advances in cystic fibrosis

S. M. Borowitz, F. K. Ghishan

Research output: Contribution to journalArticle

Abstract

Cystic fibrosis is the most common lethal genetic disorder among whites, with an incidence of 1:1600 live white births in the United States. It is a clinical syndrome characterized by generalized exocrine dysfunction. Obstructive lesions are evident throughout multiple organ systems, and diverse disturbances are observed in mucous and electrolyte secretions. Pedigree analysis suggests that cystic fibrosis is inherited as an autosomal recessive trait, with heterozygotes having no recognizable clinical symptoms. Certain characteristics of the disease suggest a polygenic mode of inheritance, but no linkage with the HLA complex or other gene loci has been demonstrated.

Original languageEnglish (US)
Pages (from-to)20-27
Number of pages8
JournalComprehensive Therapy
Volume12
Issue number2
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Advances in cystic fibrosis'. Together they form a unique fingerprint.

  • Cite this