Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

Rachel Wong, Julia A. Belk, Jennifer Govero, Jennifer L. Uhrlaub, Dakota Reinartz, Haiyan Zhao, John M. Errico, Lucas D'Souza, Tyler J. Ripperger, Janko Nikolich-Zugich, Mark J. Shlomchik, Ansuman T. Satpathy, Daved H. Fremont, Michael S. Diamond, Deepta Bhattacharya

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.

Original languageEnglish (US)
Pages (from-to)1078-1094.e7
JournalImmunity
Volume53
Issue number5
DOIs
StatePublished - Nov 17 2020

Keywords

  • Dengue virus
  • Japanese Encephalitis virus
  • West Nile virus
  • Zika virus
  • flaviruses
  • germinal center
  • memory B cells
  • plasma cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses'. Together they form a unique fingerprint.

Cite this