@article{e0f3700a0d5c42f5a7fb7298f12fcece,
title = "Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses",
abstract = "Memory B cells respond to heterologous antigens either by molding new specificities through secondary germinal centers or by selecting preexisting clones without further affinity maturation. Wong et al. show that for flavivirus challenges, secondary germinal centers minimally contribute to recall responses. Instead, preexisting cross-reactive clones are selected from a diverse memory compartment.",
keywords = "Dengue virus, Japanese Encephalitis virus, West Nile virus, Zika virus, flaviruses, germinal center, memory B cells, plasma cells",
author = "Rachel Wong and Belk, {Julia A.} and Jennifer Govero and Uhrlaub, {Jennifer L.} and Dakota Reinartz and Haiyan Zhao and Errico, {John M.} and Lucas D'Souza and Ripperger, {Tyler J.} and Janko Nikolich-Zugich and Shlomchik, {Mark J.} and Satpathy, {Ansuman T.} and Fremont, {Daved H.} and Diamond, {Michael S.} and Deepta Bhattacharya",
note = "Funding Information: This work was supported by NIH grants R01AI099108 (D.B.), K08230188 (A.T.S), P01AI106695 (M.S.D.), R01AI132186 (M.S.D.), R01AI127828 (M.S.D.), and R01AI073755 (D.H.F. and M.S.D.). R.W. was supported by the NSF Graduate Research Fellowship Program ( DGE-1143954 ). J.A.B. was supported by an NSF Graduate Research Fellowship and a Stanford Graduate Fellowship. T.J.R. was supported by NIH predoctoral training grant T32AG058503 . A.T.S. was supported by a Bridge Scholar Award from the Parker Institute for Cancer Immunotherapy , a Technology Impact Award from the Cancer Research Institute , and a Career Award for Medical Scientists from the Burroughs Wellcome Fund . We thank the Speed Congenics Facility of the Rheumatic Diseases Core, supported by NIH grant P30AR048335 . Flow cytometry experiments reported in this publication were supported by the National Cancer Institute of the NIH under award number P30CA023074 . We thank Chris Nelson and Melissa Edeling for technical support. We thank the Bioinformatics Shared Resource at the University of Arizona for assistance in bioinformatics analysis. Funding Information: This work was supported by NIH grants R01AI099108 (D.B.), K08230188 (A.T.S), P01AI106695 (M.S.D.), R01AI132186 (M.S.D.), R01AI127828 (M.S.D.), and R01AI073755 (D.H.F. and M.S.D.). R.W. was supported by the NSF Graduate Research Fellowship Program (DGE-1143954). J.A.B. was supported by an NSF Graduate Research Fellowship and a Stanford Graduate Fellowship. T.J.R. was supported by NIH predoctoral training grant T32AG058503. A.T.S. was supported by a Bridge Scholar Award from the Parker Institute for Cancer Immunotherapy, a Technology Impact Award from the Cancer Research Institute, and a Career Award for Medical Scientists from the Burroughs Wellcome Fund. We thank the Speed Congenics Facility of the Rheumatic Diseases Core, supported by NIH grant P30AR048335. Flow cytometry experiments reported in this publication were supported by the National Cancer Institute of the NIH under award number P30CA023074. We thank Chris Nelson and Melissa Edeling for technical support. We thank the Bioinformatics Shared Resource at the University of Arizona for assistance in bioinformatics analysis. D.B. M.S.D. D.H.F. and A.T.S. designed the study. M.J.S. contributed key reagents and technical advice. R.W. J.G. J.L.U. D.R. J.E. L.D.S. and T.J.R. performed experiments. R.W. J.A.B. and D.B. analyzed the data. R.W. and D.B. wrote the paper, and all other authors edited the paper. D.H.F. is a founder of Courier Therapeutics. M.S.D. is a consultant for Inbios, Vir Biotechnology, and NGM Biopharmaceuticals and on the scientific advisory board of Moderna. The Diamond laboratory has received unrelated funding under sponsored research agreements from Moderna and Emergent BioSolutions. Unrelated intellectual property of D.B. and Washington University has been licensed by Sana Biotechnology. A.T.S is an advisor for Immunai and receives funding support from Arsenal Biosciences. The remaining authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = nov,
day = "17",
doi = "10.1016/j.immuni.2020.09.001",
language = "English (US)",
volume = "53",
pages = "1078--1094.e7",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "5",
}