African-American heredity prostate cancer study: a model for genetic research.

I. J. Powell, J. Carpten, G. Dunston, Rick A Kittles, J. Bennett, G. Hoke, C. Pettaway, S. Weinrich, S. Vijayakumar, C. A. Ahaghotu, W. Boykin, T. Mason, C. Royal, A. Baffoe-Bonnie, J. Bailey-Wilson, K. Berg, J. Trent, F. Collins

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A genome-wide scan of high-risk prostate cancer families in North America has demonstrated linkage of a particular marker to Chromosome Iq (HPC11. An even greater proportion of African-American families have shown linkage to HPC 1. Therefore, investigators at the National Human Genome Research Institute [NHGRI] in collaboration with Howard University and a predominantly African-American group of urologists established the African-American Hereditary Prostate Cancer (AAHPC) Study Network to confirm the suggested linkage of HPC in African Americans with a gene on Chromosome 1. Blood samples from recruited families were sent to Howard University for extraction of DNA. The DNA was sent to NHGRI at NIH where the genotyping and genetic sequence analysis was conducted. Genotype data are merged with pedigree information so that statistical analysis can be performed to establish potential linkage. From March 1, 1998, to June 1, 1999, a total of 40 African-American families have been recruited who met the study criteria. Preliminary results suggest that racial/ethnicity grouping may affect the incidence and extent of linkage of prostate cancer to specific loci. The importance of these findings lays in the future treatment of genetic-based diseases.

Original languageEnglish (US)
JournalJournal of the National Medical Association
Volume93
Issue number12 Suppl
StatePublished - Dec 2001
Externally publishedYes

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Genetic Research
Heredity
African Americans
Prostatic Neoplasms
National Human Genome Research Institute (U.S.)
Inborn Genetic Diseases
Chromosomes, Human, Pair 1
DNA
Pedigree
North America
Genetic Markers
Sequence Analysis
Genotype
Research Personnel
Genome
Incidence
Genes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Powell, I. J., Carpten, J., Dunston, G., Kittles, R. A., Bennett, J., Hoke, G., ... Collins, F. (2001). African-American heredity prostate cancer study: a model for genetic research. Journal of the National Medical Association, 93(12 Suppl).

African-American heredity prostate cancer study : a model for genetic research. / Powell, I. J.; Carpten, J.; Dunston, G.; Kittles, Rick A; Bennett, J.; Hoke, G.; Pettaway, C.; Weinrich, S.; Vijayakumar, S.; Ahaghotu, C. A.; Boykin, W.; Mason, T.; Royal, C.; Baffoe-Bonnie, A.; Bailey-Wilson, J.; Berg, K.; Trent, J.; Collins, F.

In: Journal of the National Medical Association, Vol. 93, No. 12 Suppl, 12.2001.

Research output: Contribution to journalArticle

Powell, IJ, Carpten, J, Dunston, G, Kittles, RA, Bennett, J, Hoke, G, Pettaway, C, Weinrich, S, Vijayakumar, S, Ahaghotu, CA, Boykin, W, Mason, T, Royal, C, Baffoe-Bonnie, A, Bailey-Wilson, J, Berg, K, Trent, J & Collins, F 2001, 'African-American heredity prostate cancer study: a model for genetic research.', Journal of the National Medical Association, vol. 93, no. 12 Suppl.
Powell, I. J. ; Carpten, J. ; Dunston, G. ; Kittles, Rick A ; Bennett, J. ; Hoke, G. ; Pettaway, C. ; Weinrich, S. ; Vijayakumar, S. ; Ahaghotu, C. A. ; Boykin, W. ; Mason, T. ; Royal, C. ; Baffoe-Bonnie, A. ; Bailey-Wilson, J. ; Berg, K. ; Trent, J. ; Collins, F. / African-American heredity prostate cancer study : a model for genetic research. In: Journal of the National Medical Association. 2001 ; Vol. 93, No. 12 Suppl.
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