African and Levantine origins of Pakistani YAP+ Y chromosomes

R. Qamar, Q. Ayub, S. Khaliq, A. Mansoor, Tatiana Karafet, S. Q. Mehdi, Michael F Hammer

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We surveyed 9 Pakistani subpopulations for variation on the nonrecombining portion of the Y chromosome. The polymorphic systems examined were the Y-chromosome Alu insertion polymorphism (YAP) at DYS287, 5 single nucleotide polymorphisms, and the tetranucleotide microsatellite DYS19. Y chromosomes carrying the YAP element (YAP+) were found in populations from southwestern Pakistan at frequencies ranging from 2% to 8%, whereas northeastern populations appeared to lack YAP+ chromosomes. In contrast to other South Asian populations, several Pakistani subpopulations had a high frequency of the DYSJ9*B allele, the most frequent allele in West Asian, North African, and European populations. The combination of alleles at all polymorphic sites gave rise to 9 YAP-DYS19 combination haplotypes in Pakistani populations, including YAP+ haplotypes 4-A, 4-B, 5-C, and 5-E. We hypothesize that the geographic distributions of YAP+ haplotypes 4 and 5 trace separate migratory routes to Pakistan: YAP+ haplotype 5 may have entered Pakistan from the Arabian Peninsula by means of migrations across the Gulf of Oman, whereas males possessing YAP+ haplotype 4 may have traveled over land from the Middle East. These inferences are consistent with ethnohistorical data suggesting that Pakistan's ethnic groups have been influenced by migrations from both African and Levantine source populations.

Original languageEnglish (US)
Pages (from-to)745-755
Number of pages11
JournalHuman Biology
Volume71
Issue number5
StatePublished - Oct 1999

Fingerprint

Y Chromosome
Y chromosome
polymorphism
chromosome
genetic polymorphism
Haplotypes
Pakistan
haplotypes
Population
allele
Alleles
alleles
subpopulation
Oman
Middle East
migration route
nationalities and ethnic groups
ethnic group
Ethnic Groups
Microsatellite Repeats

Keywords

  • Male migration
  • Pakistan
  • Y-chromosome haplotypes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Qamar, R., Ayub, Q., Khaliq, S., Mansoor, A., Karafet, T., Mehdi, S. Q., & Hammer, M. F. (1999). African and Levantine origins of Pakistani YAP+ Y chromosomes. Human Biology, 71(5), 745-755.

African and Levantine origins of Pakistani YAP+ Y chromosomes. / Qamar, R.; Ayub, Q.; Khaliq, S.; Mansoor, A.; Karafet, Tatiana; Mehdi, S. Q.; Hammer, Michael F.

In: Human Biology, Vol. 71, No. 5, 10.1999, p. 745-755.

Research output: Contribution to journalArticle

Qamar, R, Ayub, Q, Khaliq, S, Mansoor, A, Karafet, T, Mehdi, SQ & Hammer, MF 1999, 'African and Levantine origins of Pakistani YAP+ Y chromosomes', Human Biology, vol. 71, no. 5, pp. 745-755.
Qamar R, Ayub Q, Khaliq S, Mansoor A, Karafet T, Mehdi SQ et al. African and Levantine origins of Pakistani YAP+ Y chromosomes. Human Biology. 1999 Oct;71(5):745-755.
Qamar, R. ; Ayub, Q. ; Khaliq, S. ; Mansoor, A. ; Karafet, Tatiana ; Mehdi, S. Q. ; Hammer, Michael F. / African and Levantine origins of Pakistani YAP+ Y chromosomes. In: Human Biology. 1999 ; Vol. 71, No. 5. pp. 745-755.
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