Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma

Marlon A Guerrero, Insoo Suh, Menno R. Vriens, Wen T. Shen, Jessica Gosnell, Electron Kebebew, Quan Yang Duh, Orlo H. Clark

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction: Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. Methods: A retrospective analysis was performed on all patients diagnosed with HCC on final pathology between 1997 and 2008. The tumor size and lymph node status was obtained for each patient. The data were analyzed utilizing Student's t-test and the Fisher's exact test to calculate the two-tailed p-value. Results: Out of 39 patients diagnosed with HCC 3(8%) had LN metastases; 1 had ipsilateral central LN metastasis and 2 had ipsilateral central and lateral LN metastasis. LN dissection was performed in patients with known metastasis (2 were evident on preoperative ultrasound and 1 intraoperatively). Patients with LN metastasis were older than those without (mean age: 86.7 and 56.4 years, respectively), had larger tumors (mean size: 6 and 4 cm) and were commonly male (2 of 3). No tumor < 5cm presented with lymph node involvement (3/15 with >5cm cancer had node metastasis, 0/24 with <5cm cancer had node metastasis). Conclusions: Similar to what has been found in patients with papillary thyroid cancer, older male patients with Hürthle cell carcinomas greater than 5cm are more likely to have lymph node metastasis. Our data suggest that these patients may benefit from a prophylactic ipsilateral central neck dissection at the time of their initial operation.

Original languageEnglish (US)
Pages (from-to)23-26
Number of pages4
JournalJournal of Cancer
Volume1
Issue number1
StatePublished - 2010

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Lymph Nodes
Neoplasm Metastasis
Carcinoma
Neoplasms
Cell Size
Neck Dissection
Lymph Node Excision
Pathology
Students

Keywords

  • Age
  • Hurthle cell carcinoma
  • Lymph node metastasis
  • Prediction
  • Tumor size

ASJC Scopus subject areas

  • Oncology

Cite this

Guerrero, M. A., Suh, I., Vriens, M. R., Shen, W. T., Gosnell, J., Kebebew, E., ... Clark, O. H. (2010). Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma. Journal of Cancer, 1(1), 23-26.

Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma. / Guerrero, Marlon A; Suh, Insoo; Vriens, Menno R.; Shen, Wen T.; Gosnell, Jessica; Kebebew, Electron; Duh, Quan Yang; Clark, Orlo H.

In: Journal of Cancer, Vol. 1, No. 1, 2010, p. 23-26.

Research output: Contribution to journalArticle

Guerrero, MA, Suh, I, Vriens, MR, Shen, WT, Gosnell, J, Kebebew, E, Duh, QY & Clark, OH 2010, 'Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma', Journal of Cancer, vol. 1, no. 1, pp. 23-26.
Guerrero MA, Suh I, Vriens MR, Shen WT, Gosnell J, Kebebew E et al. Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma. Journal of Cancer. 2010;1(1):23-26.
Guerrero, Marlon A ; Suh, Insoo ; Vriens, Menno R. ; Shen, Wen T. ; Gosnell, Jessica ; Kebebew, Electron ; Duh, Quan Yang ; Clark, Orlo H. / Age and tumor size predicts lymph node involvement in Hürthle cell carcinoma. In: Journal of Cancer. 2010 ; Vol. 1, No. 1. pp. 23-26.
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AU - Gosnell, Jessica

AU - Kebebew, Electron

AU - Duh, Quan Yang

AU - Clark, Orlo H.

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N2 - Introduction: Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. Methods: A retrospective analysis was performed on all patients diagnosed with HCC on final pathology between 1997 and 2008. The tumor size and lymph node status was obtained for each patient. The data were analyzed utilizing Student's t-test and the Fisher's exact test to calculate the two-tailed p-value. Results: Out of 39 patients diagnosed with HCC 3(8%) had LN metastases; 1 had ipsilateral central LN metastasis and 2 had ipsilateral central and lateral LN metastasis. LN dissection was performed in patients with known metastasis (2 were evident on preoperative ultrasound and 1 intraoperatively). Patients with LN metastasis were older than those without (mean age: 86.7 and 56.4 years, respectively), had larger tumors (mean size: 6 and 4 cm) and were commonly male (2 of 3). No tumor < 5cm presented with lymph node involvement (3/15 with >5cm cancer had node metastasis, 0/24 with <5cm cancer had node metastasis). Conclusions: Similar to what has been found in patients with papillary thyroid cancer, older male patients with Hürthle cell carcinomas greater than 5cm are more likely to have lymph node metastasis. Our data suggest that these patients may benefit from a prophylactic ipsilateral central neck dissection at the time of their initial operation.

AB - Introduction: Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. Methods: A retrospective analysis was performed on all patients diagnosed with HCC on final pathology between 1997 and 2008. The tumor size and lymph node status was obtained for each patient. The data were analyzed utilizing Student's t-test and the Fisher's exact test to calculate the two-tailed p-value. Results: Out of 39 patients diagnosed with HCC 3(8%) had LN metastases; 1 had ipsilateral central LN metastasis and 2 had ipsilateral central and lateral LN metastasis. LN dissection was performed in patients with known metastasis (2 were evident on preoperative ultrasound and 1 intraoperatively). Patients with LN metastasis were older than those without (mean age: 86.7 and 56.4 years, respectively), had larger tumors (mean size: 6 and 4 cm) and were commonly male (2 of 3). No tumor < 5cm presented with lymph node involvement (3/15 with >5cm cancer had node metastasis, 0/24 with <5cm cancer had node metastasis). Conclusions: Similar to what has been found in patients with papillary thyroid cancer, older male patients with Hürthle cell carcinomas greater than 5cm are more likely to have lymph node metastasis. Our data suggest that these patients may benefit from a prophylactic ipsilateral central neck dissection at the time of their initial operation.

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