Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above and beyond the changes seen in the aging of T-cell pool in the absence of TCE. This chapter discusses our current knowledge of the role of these expansions in health and disease, with a special focus on their influence upon immune defense against infectious diseases.

Original languageEnglish (US)
Title of host publicationHandbook on Immunosenescence
Subtitle of host publicationBasic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages219-233
Number of pages15
ISBN (Electronic)9781402090639
ISBN (Print)9781402090622
DOIs
StatePublished - Jan 1 2009

Keywords

  • Ageing
  • Clonal expansions
  • Homeostasis
  • Infectious diseases
  • T-cells

ASJC Scopus subject areas

  • Medicine(all)

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    Nikolich-Žugich, J., & Lang, A. (2009). Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 219-233). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-12