Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Age-related T-cell clonal expansions (TCE) are an incompletely understood disturbance in T-cell homeostasis found frequently in old humans and experimental animals. These accumulations of CD8 T-cells have the potential to distort T-cell population balance and reduce T-cell repertoire diversity above and beyond the changes seen in the aging of T-cell pool in the absence of TCE. This chapter discusses our current knowledge of the role of these expansions in health and disease, with a special focus on their influence upon immune defense against infectious diseases.

Original languageEnglish (US)
Title of host publicationHandbook on Immunosenescence: Basic Understanding and Clinical Applications
PublisherSpringer Netherlands
Pages219-233
Number of pages15
ISBN (Print)9781402090639, 9781402090622
DOIs
StatePublished - 2009

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T-Lymphocytes
Communicable Diseases
Homeostasis
Health
Population

Keywords

  • Ageing
  • Clonal expansions
  • Homeostasis
  • Infectious diseases
  • T-cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nikolich-Zugich, J., & Lang, A. (2009). Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 219-233). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-12

Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. / Nikolich-Zugich, Janko; Lang, Anna.

Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, 2009. p. 219-233.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nikolich-Zugich, J & Lang, A 2009, Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. in Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, pp. 219-233. https://doi.org/10.1007/978-1-4020-9063-9-12
Nikolich-Zugich J, Lang A. Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands. 2009. p. 219-233 https://doi.org/10.1007/978-1-4020-9063-9-12
Nikolich-Zugich, Janko ; Lang, Anna. / Age-associated T-cell clonal expansions (TCE) in vivo-implications for pathogen resistance. Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, 2009. pp. 219-233
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