Age-based disparity in outcomes of intestinal transplants in pediatric patients

C. S. Desai, F. B. Maegawa, A. C. Gruessner, R. W. Gruesner, K. M. Khan

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Outcomes of intestinal transplants (ITx; n = 977) for pediatric patients are examined using the United Network for Organ Sharing data from 1987 to 2009. Recipients were divided into four age groups: (1) <2 years of age (n = 569), (2) 2-6 years (n = 219), (3) 6-12 years (n = 121) and (4) 12-18 years (n = 68). Of 977 ITx, 287 (29.4%) were isolated ITx and 690 (70.6%) were liver and ITx (L-ITx). Patient survival for isolated ITx at 1, 3 and 5 years, 85.3%, 71.3% and 65.0%, respectively, was significantly better than L-ITx, 68.4%, 57.0% and 51.4%, respectively, (p = 0.0001); this was true for all age groups, except for patients <2 years of age. The difference in graft survival between isolated ITx and L-ITx was significant at 1 and 3 years (Wilcoxon test, p = 0.0012). After attrition analysis of graft survival of patients who survived past first year, 3 and 5 years, graft survival for L-ITx patient was significantly better than those for isolated ITx. Isolated ITx should be considered early before the onset of liver disease in children >2 with intestinal failure but is not advantageous in patients <2 years.

Original languageEnglish (US)
Pages (from-to)S43-S48
JournalAmerican Journal of Transplantation
Volume12
Issue numberSUPPL 4
DOIs
StatePublished - Jan 1 2012

Keywords

  • Intestine
  • Multivisceral
  • Pediatrics
  • Survival
  • Transplant

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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