Age-dependent (+)MDMA-mediated neurotoxicity in mice

Maria Elena Reveron, Terrence J. Monks, Christine L. Duvauchelle

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In the present study the effects of a neurotoxic regimen of (+)-MDMA (20 mg/kg × 4, s.c.) in 4- and 10-week-old C57Bl/6J mice during treatment and 7 days post-treatment were examined. Rectal temperatures monitored between (+)-MDMA injections (30 min post-injection/2 h intervals) revealed hyperthermic responses in both age groups, with the magnitude of the response significantly greater in older mice. Seven days post-treatment, immunoblot analyses of the vesicular monoamine transporter 2 (VMAT2), and tyrosine hydroxylase (TH) revealed significant reductions (-37 and -58%, respectively) in the older animals, but not in the younger group, compared to age-matched controls. Dopamine transporter (DAT) expression was significantly reduced in both 4- and 10-week-old animals (26 and 69.7%, respectively). (+)-MDMA-treated animals also exhibited significantly lower levels of striatal dopamine, and 3,4-dihydroxyphenylacetic acid than controls, again the effect being more pronounced in the older animals. Although both age groups showed evidence of (+)-MDMA-induced toxicity, our data revealed that older animals exhibited a greater hyperthermic response to (+)-MDMA and were also are more susceptible to subsequent dopaminergic damage than the younger animals

Original languageEnglish (US)
Pages (from-to)1031-1040
Number of pages10
JournalNeuroToxicology
Volume26
Issue number6
DOIs
StatePublished - Dec 1 2005

Keywords

  • Dopamine
  • MDMA
  • Mice
  • Microdialysis
  • Temperature
  • VMAT2

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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